Surfaceome and Proteosurfaceome in Parietal Monoderm Bacteria: Focus on Protein Cell-Surface Display

Frontiers in Microbiology
Mickaël DesvauxPascale Serror

Abstract

The cell envelope of parietal monoderm bacteria (archetypal Gram-positive bacteria) is formed of a cytoplasmic membrane (CM) and a cell wall (CW). While the CM is composed of phospholipids, the CW is composed at least of peptidoglycan (PG) covalently linked to other biopolymers, such as teichoic acids, polysaccharides, and/or polyglutamate. Considering the CW is a porous structure with low selective permeability contrary to the CM, the bacterial cell surface hugs the molecular figure of the CW components as a well of the external side of the CM. While the surfaceome corresponds to the totality of the molecules found at the bacterial cell surface, the proteinaceous complement of the surfaceome is the proteosurfaceome. Once translocated across the CM, secreted proteins can either be released in the extracellular milieu or exposed at the cell surface by associating to the CM or the CW. Following the gene ontology (GO) for cellular components, cell-surface proteins at the CM can either be integral (GO: 0031226), i.e., the integral membrane proteins, or anchored to the membrane (GO: 0046658), i.e., the lipoproteins. At the CW (GO: 0009275), cell-surface proteins can be covalently bound, i.e., the LPXTG-proteins, or bound through wea...Continue Reading

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Citations

Nov 21, 2018·Omics : a Journal of Integrative Biology·Julia EsbelinMichel Hébraud
Aug 29, 2019·Frontiers in Microbiology·Tina Vida PlavecAleš Berlec
May 16, 2020·Frontiers in Bioengineering and Biotechnology·Moira GiovannoniBenedetta Mattei
May 10, 2019·Frontiers in Nutrition·Rosa Anna SicilianoMaria Fiorella Mazzeo
Jun 5, 2019·FEMS Microbiology Reviews·Lucie Etienne-MesminStéphanie Blanquet-Diot
Feb 16, 2021·Frontiers in Bioengineering and Biotechnology·Pei Kun Richie TayDave Siak-Wei Ow
Feb 26, 2021·Biotechnology Advances·Hao DongPing Wang

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Datasets Mentioned

BETA
SSF54106
SM00728

Methods Mentioned

BETA
electron microscopy
lipidation
environmental stresses
transmission electron microscopy
glycosylation

Software Mentioned

Prosite
PSORT
ms
SignalP
InterProScan
IMPs
InterPro

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