Surfactant Administration During Pediatric Cardiac Extracorporeal Membrane Oxygenation

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Constantinos ChrysostomouPeter Wearden

Abstract

We investigated the safety and efficacy of surfactant during extracorporeal membrane oxygenation (ECMO) in children with cardiac disease. ECMO patients administered surfactant (surfactant group) were compared with patients who did not receive (control). Criteria to administer surfactant were based on a decreased lung compliance of <0.5 ml/kg/cm H2O. Efficacy was determined on pulmonary compliance change and the radiography-based respiratory distress severity (RDS) score. For the surfactant group, lung compliance measurements and RDS scores were obtained just before the first surfactant administration (T0), 24 hours after the last dose of surfactant (T1), and 24 hours after ECMO decannulation (T2). For the control group, measurements were obtained at baseline (T0), day of ECMO decannulation (T1), and 24 hours after ECMO decannulation (T2). Eighty were on ECMO, 29 in the surfactant, and 51 in the control group. Surfactant group was younger 20 (6-140) vs. 28 (8-928) days old (p = 0.03), had longer ECMO duration 110 (58-192) vs. 46 (29-84) hours (p = 0.001), and had longer mechanical ventilation 16 (11-26) vs. 7 (5-9) days (p = 0.003). The lung compliance and RDS scores in the surfactant group improved significantly between baselin...Continue Reading

References

Jun 26, 2001·Acta Anaesthesiologica Scandinavica·V Brix-Christensen
Nov 11, 2005·Critical Care : the Official Journal of the Critical Care Forum·Michael HermonGerhard Trittenwein
Jul 12, 2011·Critical Care Clinics·Krishnan RaghavendranR H Notter
Oct 20, 2011·Respiratory Care·Ira M Cheifetz
Dec 12, 2012·The Journal of Thoracic and Cardiovascular Surgery·Constantinos ChrysostomouPeter D Wearden

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Citations

Sep 10, 2019·Frontiers in Pediatrics·Peter Paul Roeleveld, Malaika Mendonca

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