Surfactant administration for neonatal respiratory distress does not improve lung interstitial fluid clearance: echographic and experimental evidence

Journal of Perinatal Medicine
Luigi CattarossiGiuseppe Miserocchi

Abstract

Recent ultrasonographic studies suggest that the administration of surfactant to preterm infants with respiratory distress syndrome (RDS) does not affect lung water clearance. The purpose of the study was also to look at clearance of lung water in preterm rabbits receiving surfactant. Lung ultrasound was performed in 73 neonates at different gestational ages (range 23-34 weeks) with radiological and clinical signs of RDS, before and after surfactant administration. In premature rabbits (28-29 days' gestational age), either receiving or not receiving surfactant, we followed the time course of lung water balance considering the wet weight/dry weight ratio, the morphology and compliance of alveoli and pulmonary interstitial pressure. In all RDS infants lung ultrasound images consistently showed a generalized increase in extravascular lung fluid which remained unchanged after surfactant administration and did not affect the rate of fluid clearance. Surfactant administration in premature rabbits did not improve the time course of lung fluid clearance. Data from ultrasound in preterm babies are confirmed by animal experiments.

References

Nov 1, 1991·Journal of Applied Physiology·G MiserocchiC Gonano
Dec 1, 1990·Journal of Applied Physiology·G MiserocchiC Gonano
Nov 1, 1994·Journal of Applied Physiology·G MiserocchiM Del Fabbro
Mar 1, 1993·American Journal of Respiratory Cell and Molecular Biology·K M WeidnerW Birchmeier
Dec 1, 1995·Respiration Physiology·G MiserocchiB Crisafulli
Dec 31, 1997·American Journal of Respiratory and Critical Care Medicine·D LichtensteinO Barré
Feb 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yiqiong WangPhilip L Sannes
Mar 20, 2004·Pediatric Pulmonology. Supplement·Hugh O'Brodovich
Jun 9, 2005·Critical Care Medicine·Daniel A LichtensteinMarc Tenoudji-Cohen
Apr 15, 2006·Development·Wellington V Cardoso, Jining Lü
Aug 19, 2006·Circulation Research·Fotini M Kouri, Oliver Eickelberg
Feb 20, 2007·American Journal of Obstetrics and Gynecology·Avroy A FanaroffUNKNOWN NICHD Neonatal Research Network
Dec 7, 2007·European Journal of Applied Physiology·G MiserocchiE Beretta
Jan 17, 2008·Neonatology·Roberto CopettiRiccardo Furlan
Jan 27, 2009·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Gino SoldatiSara Sher

❮ Previous
Next ❯

Citations

Mar 13, 2014·Pediatric Radiology·Francesco RaimondiRoberto Copetti
Feb 18, 2016·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·N Yousef
Jul 3, 2013·Early Human Development·Luigi Cattarossi
Mar 3, 2011·Chest·Luigi CattarossiBesa Poskurica
Sep 6, 2011·Radiologic Clinics of North America·Brian D Coley
Apr 19, 2016·Journal of Paediatrics and Child Health·Douglas A BlankGraeme R Polglase
Jan 21, 2015·Respiratory Physiology & Neurobiology·Caterina SalitoGiuseppe Miserocchi
Jul 1, 2017·Archives of Disease in Childhood. Fetal and Neonatal Edition·Douglas A BlankPeter G Davis
Aug 23, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Noah H HillmanAlan H Jobe
Jul 13, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Dilek DilliAysegul Zenciroğlu
Sep 20, 2019·Acta Paediatrica·Arrabella KingAtul Malhotra
Oct 28, 2019·European Journal of Pediatrics·Rebeca Gregorio-HernándezManuel Sánchez-Luna
Nov 11, 2018·Archives of Disease in Childhood·Patricia Lee Woods
Jun 9, 2020·Pediatric Pulmonology·Carla Maria Irene QuaratoMarco Sperandeo
Aug 6, 2020·Pediatric Pulmonology·Alessandro PerriGiovanni Vento
Dec 29, 2020·Pediatric Pulmonology·Victoria Aldecoa-BilbaoMªDolors Salvia Roigés
Nov 27, 2019·American Journal of Perinatology·Davut BozkayaŞerife Suna Oğuz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
Fabrizio EliaFranco Aprà
Paediatric Respiratory Reviews
Mark J Hogan, Brian D Coley
Radiographics : a Review Publication of the Radiological Society of North America, Inc
H K Rosenberg
The American Journal of Emergency Medicine
Giovanni Volpicelli
© 2021 Meta ULC. All rights reserved