PMID: 8980964Dec 1, 1996Paper

Surfactant apoprotein-A concentration in airway secretions for the detection of pulmonary oedema

The European Respiratory Journal
S ShimuraK Shirato

Abstract

Patients with cardiogenic pulmonary oedema expectorate foamy sputum containing surfactant, which might be expected to include surfactant apoprotein A (SP-A). SP-A is specific for lung surfactant. We have measured the SP-A concentration in airway secretions to determine whether it is useful in distinguishing pulmonary oedema from other disorders. Samples of sputum and of aspirated airway secretion were obtained from 11 patients with cardiogenic pulmonary oedema, seven patients with clinically stable congestive heart failure, five patients with adult respiratory distress syndrome (ARDS) and 20 control patients (10 intubated) with other respiratory diseases. The samples were used for the measurement of SP-A concentration by a two-site simultaneous immunoassay with monoclonal antibodies against SP-A. SP-A concentrations, measured in samples of sputum and aspirated secretions, depended on the diagnosis of the patients from which they had come. In descending order these samples came from patients with: cardiogenic pulmonary oedema (1324 +/- 197 micrograms.mL-1; n = 33); ARDS (311 +/- 47 micrograms.mL-1; n = 23); clinically stable congestive heart failure (78 +/- 10 micrograms.mL-1; n = 21); and control conditions (3.0 +/- 0.6 microgr...Continue Reading

Citations

May 24, 2000·Cellular Signalling·S Shimura
Feb 2, 1999·American Journal of Respiratory and Critical Care Medicine·C Hermans, A Bernard
Nov 4, 2000·American Journal of Respiratory Cell and Molecular Biology·F E BarrV L Shepherd
Mar 17, 2009·Diagnostic Pathology·Torsten GoldmannEkkehard Vollmer
Sep 3, 2016·The European Respiratory Journal·William J JanssenChristopher M Evans
Aug 27, 2017·Critical Care : the Official Journal of the Critical Care Forum·Kosaku KomiyaBruce K Rubin
Aug 5, 1998·The American Journal of Physiology·R J MasonD R Voelker
Dec 4, 2013·Current Opinion in Critical Care·Alexandra BinnieClaudia C dos Santos

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