Surfactant Driven Post-Deposition Spreading of Aerosols on Complex Aqueous Subphases. 2: Low Deposition Flux Representative of Aerosol Delivery to Small Airways

Journal of Aerosol Medicine and Pulmonary Drug Delivery
Ramankur SharmaRobert D Tilton

Abstract

Cystic fibrosis (CF) is associated with the accumulation of dehydrated mucus in the pulmonary airways. This alters ventilation and aerosol deposition patterns in ways that limit drug delivery to peripheral lung regions. We investigated the use of surfactant-based, self-dispersing aerosol carriers that produce surface tension gradients to drive two-dimensional transport of aerosolized medications via Marangoni flows after deposition on the airway surface liquid (ASL). We considered the post-deposition spreading of individual aerosol droplets and two-dimensional expansion of a field of aerosol droplets, when deposited at low fluxes that are representative of aerosol deposition in the small airways. We used physically entangled aqueous solutions of poly(acrylamide) or porcine gastric mucin as simple ASL mimics that adequately capture the full miscibility but slow penetration of entangled macromolecular chains of the ASL into the deposited drop. Surfactant formulations were prepared with aqueous solutions of nonionic tyloxapol or FS-3100 fluorosurfactant. Fluorescein dye served as a model "drug" tracer and to visualize the extent of post-deposition spreading. The surfactants not only enhanced post-deposition spreading of individual...Continue Reading

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Citations

Sep 14, 2016·Journal of Colloid and Interface Science·Amy Z StettenRobert D Tilton
May 10, 2017·Colloids and Surfaces. A, Physicochemical and Engineering Aspects·Ramankur SharmaRobert D Tilton
Aug 28, 2018·Current Opinion in Colloid & Interface Science·Amy Z StettenRobert D Tilton
Oct 15, 2021·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Nicholas D HagesTimothy E Corcoran

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