Surfactant-facilitated crystallisation of water-soluble foldamers

Chemical Science
Gavin W CollieGilles Guichard

Abstract

X-ray crystallography has played a major role in the advancement of foldamer research, however, obtaining well-formed single crystals of suitable quality for structure determination by X-ray diffraction methods is often rather challenging. Towards this end, we report here the ability of common surfactants to promote the crystallisation of a series of water-soluble oligourea foldamers which had previously proven highly resistant to crystallisation. Four high-resolution crystal structures are reported, suggesting certain surfactants could be potentially useful tools for the crystallisation of intractable water-soluble foldamers (or peptides).

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Citations

Oct 21, 2016·Chemistry : a European Journal·Vincent DiemerGilles Guichard
May 29, 2018·Chemistry : a European Journal·Fredy SussmanRamón J Estévez

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Methods Mentioned

BETA
X-ray
co-crystallisation

Software Mentioned

PyMOL

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