Surfactant in the preterm infant: what's going on

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Carlo DaniGiovanna Bertini

Abstract

Surfactant treatment has been demonstrated to decrease pneumothorax and mortality in preterm infants. Natural surfactants are better than synthetic surfactants. Early rescue treatment with surfactant is better than late treatment, whereas the role of surfactant prophylaxis is under re-evaluation due to the actual large diffusion of antenatal steroid and nasal continuous positive airway pressure treatment which have changed the clinical characteristics of preterm infants with respiratory distress syndrome. It is possible that in the next future anti-inflammatory and anti-oxidant properties of exogenous natural surfactants may be improved through their combination with adequate agents with the aim of counteracting the pathogenetic role of inflammatory and oxidative lung injury injuries in the development of brochopulmonary dysplasia.

References

Aug 17, 1990·Biochimica Et Biophysica Acta·S MatalonB A Freeman
Nov 1, 1985·Journal of Applied Physiology·B A HolmS Matalon
Apr 2, 2003·Seminars in Neonatology : SN·Ola Didrik Saugstad
Apr 5, 2005·Pediatrics·Sunil K SinhaUNKNOWN Surfaxin Therapy Against Respiratory Distress Syndrome Collaborative Group
Feb 5, 2008·Pediatrics·William A Engle, UNKNOWN American Academy of Pediatrics Committee on Fetus and Newborn
Feb 15, 2008·The New England Journal of Medicine·Colin J MorleyUNKNOWN COIN Trial Investigators

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Citations

Mar 10, 2011·Archives of Gynecology and Obstetrics·Yun WangTore Henriksen

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