PMID: 7544813Sep 1, 1995Paper

Surfactant-induced dermatitis: comparison of corneosurfametry with predictive testing on human and reconstructed skin

Journal of the American Academy of Dermatology
G E PiérardClaudine Piérard-Franchimont

Abstract

Surfactants elicit alterations in the stratum corneum. Predictive tests that avoid animal experimentation are needed. This study compares three methods of rating and predicting shampoo-induced irritation. Corneosurfametry entails collection of stratum corneum followed by brief contact with diluted surfactants and measurement of variations in staining of samples. Corneosurfametry appears to correlate well with in vivo testing in volunteers with sensitive skin. However, corneosurfametry presents less interindividual variability than in vivo testing and allows better discrimination among mild products. Morphologic information about surfactant-induced loosening of corneocytes may be increased by testing surfactants on human skin equivalent. Results are similar to those provided by specimens used for corneosurfametry. The corneosurfametric prediction of surfactant irritancy correlates with in vivo testing and with in vitro evaluation on human skin equivalent.

References

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Citations

Jul 1, 1996·Archives of Dermatological Research·V Goffin, G E Piérard
Aug 24, 1999·Clinical and Experimental Dermatology·V GoffinG E Piérard
Feb 1, 1996·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·G E Piérard
Nov 1, 1997·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·V GoffinG E Piérard
Nov 6, 2004·Skin Pharmacology and Physiology·M Gloor
Jul 29, 2008·Journal of Occupational Medicine and Toxicology·Emmanuelle Xhauflaire-UhodaGérald E Piérard
Apr 5, 2011·Plastic and Reconstructive Surgery·Pauline D H M VerhaegenPaul P M van Zuijlen
May 22, 2008·International Journal of Cosmetic Science·G Primavera, E Berardesca
Sep 16, 2008·Journal of Cosmetic Dermatology·Emmanuelle Xhauflaire-UhodaGérald E Piérard
Sep 2, 2014·TheScientificWorldJournal·Gérald E PiérardPhilippe Delvenne
Jul 19, 2011·Expert Opinion on Biological Therapy·Claudine Piérard-FranchimontPascale Quatresooz
Oct 5, 2010·Dermatologic Clinics·Bethanee J Schlosser
Apr 2, 2003·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M Gloor, W Gehring
Jan 21, 2004·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Max GloorJoachim W Fluhr
Mar 18, 2004·Contact Dermatitis·E UhodaG E Pierard
Apr 20, 2007·Contact Dermatitis·Pascale QuatresoozGérald E Piérard
Jun 26, 2001·Journal of Clinical Pharmacy and Therapeutics·P OdouH Robert
Feb 1, 1996·Contact Dermatitis·V GoffinG E Piérard

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