Surfactant-induced Marangoni transport of lipids and therapeutics within the lung

Current Opinion in Colloid & Interface Science
Amy Z StettenRobert D Tilton

Abstract

Understanding the fundamentals of surface transport on thin viscous films has important application in pulmonary drug delivery. The human lung contains a large-area interface between its complex fluid lining and inhaled air. Marangoni flows driven by surface tension gradients along this interface would promote enhanced distribution of inhaled therapeutics by carrying them from where they are deposited in the upper airways, along the fluid interface to deeper regions of the lung. Motivated by the potential to improve therapies for acute and chronic lung diseases, we review recent progress in modeling and experimental studies of Marangoni transport induced by the deposition of surfactant-containing microliter drops and liquid aerosols (picoliter drops) onto a fluid interface. The roles of key system variables are identified, including surfactant solubility, drop miscibility with the subphase, and the thickness, composition and surface properties of the subphase liquid. Of particular interest is the unanticipated but crucial role of aerosol processing to achieve Marangoni transport via phospholipid vesicle dispersions, which are likely candidates for a biocompatible delivery system. Progress in this field has the potential to not ...Continue Reading

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Citations

May 1, 2021·Soft Matter·Clara O Ciutara, Joseph A Zasadzinski
Jun 11, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Guangle LiYi Y Zuo
Oct 15, 2021·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Nicholas D HagesTimothy E Corcoran
Nov 12, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Zhongyuan NiDongsheng Wen

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