Surfactant-mediated dissolution: contributions of solubility enhancement and relatively low micelle diffusivity

Journal of Pharmaceutical Sciences
Anand BalakrishnanJames E Polli

Abstract

The objective of this study was to assess the contributions of surfactant-mediated solubility and micellar diffusivity on the ability of surfactant to enhance drug dissolution. The following model was derived to predict the degree to which surfactants enhance griseofulvin dissolution: phi = 1 + (fm/ff).((D(D-M)2/3)/(DD2/3)) where phi is the degree of surfactant-mediated dissolution enhancement, fm is the fraction of the drug in micelle, and ff is the fraction of free drug, and DD and D(D-M) are the diffusivities of free drug and drug-loaded micelles, respectively. The Wood apparatus was used to measure the dissolution of griseofluvin in the presence of the anionic surfactant sodium dodecyl sulfate (SDS), the cationic surfactant cetyl trimethyl ammonium bromide (CTAB), and the neutral surfactants Tween 80 and Cremophor EL. DD was estimated using the Levich equation. D(D-M) was measured using dynamic light scattering. Griseofulvin solubility was evaluated in SDS, CTAB, Tween 80, and Cremophor EL at the surfactant concentrations used in the dissolution studies. DD was 11.0 x 10(-6) cm2/s. D(D-M) was 1.29 x 10(-6) cm2/s, 0.956 x 10(-6) cm2/s, 0.569 x 10(-6) cm2/s, and 0.404 x 10(-6) cm2/s for griseofulvin-loaded micelles of SDS, CT...Continue Reading

References

May 1, 1970·Journal of Pharmaceutical Sciences·M Gibaldi, S Feldman
May 1, 1970·Journal of Pharmaceutical Sciences·P KabasakalianE Townley
Sep 1, 1971·Journal of Pharmaceutical Sciences·W L Chiou, S Riegelman
Nov 1, 1981·Scientific American·F Moog
Jan 11, 1980·Journal of Chromatography·H ZiaJ K Ma
Oct 31, 1997·Journal of Pharmaceutical Sciences·V M RaoM Z Southard
Apr 17, 1999·International Journal of Pharmaceutics·M J Ginski, J E Polli
Sep 1, 1987·Journal of Pharmaceutical Sciences·J H de SmidtD J Crommelin
Feb 15, 2001·Journal of Pharmaceutical Sciences·P E Luner, D Vander Kamp
Mar 29, 2001·Journal of Pharmacological and Toxicological Methods·C A Lipinski
Jan 5, 2002·Pharmaceutical Development and Technology·L TangN A Muhammad
Sep 3, 2002·International Journal of Pharmaceutics·Nina NiSamuel Yalkowsky

❮ Previous
Next ❯

Citations

Feb 3, 2009·Molecular Pharmaceutics·Jennifer J ShengGordon L Amidon
Apr 6, 2006·AAPS PharmSciTech·Viral F Patel, Natavarlal M Patel
Apr 24, 2008·AAPS PharmSciTech·Marta Fernandez-TarrioAngel Concheiro
Dec 29, 2011·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Tarique Ali MeerPurnima D Amin
Mar 13, 2014·International Journal of Pharmaceutics·Ulla Brinkmann-Trettenes, Annette Bauer-Brandl
Jun 1, 2013·Drug Delivery and Translational Research·Meer Tarique AliPurnima Amin
Apr 1, 2009·Expert Opinion on Drug Metabolism & Toxicology·Kiyohiko Sugano
Jun 6, 2008·Expert Opinion on Drug Delivery·Michael Bur, Claus-Michael Lehr
Aug 8, 2014·Journal of Pharmaceutical Sciences·William Wei Lim ChinRajeev Gokhale
May 20, 2015·Journal of Pharmaceutical Sciences·Lennart LindforsBertil Abrahamsson
Oct 17, 2014·Journal of Pharmaceutical Sciences·Lenka StarýchováKlára Gardavská
Sep 10, 2009·Journal of Pharmaceutical Sciences·Radhakrishna K MarojuHailing Zhang
Feb 20, 2014·Journal of Pharmaceutical Sciences·Divyakant DesaiPeter Timmins
Sep 11, 2007·Journal of Pharmaceutical Sciences·Arimichi OkazakiKiyohiko Sugano
Feb 24, 2011·Journal of Pharmaceutical Sciences·Sateesh Kumar SathigariR Jayachandra Babu
Jan 10, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Shalaka DhatBirendra Shrivastava
Feb 5, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Wusheng ZhuM Silvina Tomassone
Oct 24, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fulden BuyukozturkRebecca L Carrier
Oct 20, 2007·International Journal of Pharmaceutics·Srinivas MutalikAchutha Nayak Usha
Feb 10, 2007·Journal of Dermatological Science·S Narasimha MurthyChristopher Paul Bowers
Sep 11, 2007·Drug Metabolism and Pharmacokinetics·Kiyohiko SuganoTakashi Mano
Apr 19, 2015·International Journal of Pharmaceutics·Scott M KrullRajesh N Davé
Oct 18, 2011·International Journal of Pharmaceutics·Pranabesh Dutta, Joykrishna Dey
Aug 18, 2009·Macromolecular Bioscience·Pranabesh DuttaJoykrishna Dey
Oct 24, 2012·Lab on a Chip·Yunhan ChenSindy K Y Tang
Jul 25, 2019·Physical Review. E·Herve NganguiaY-N Young
Jan 29, 2020·The AAPS Journal·Deanna M MudieChristel A S Bergström
Jun 14, 2019·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Daniela Amaral SilvaRaimar Löbenberg
Aug 12, 2010·Molecular Pharmaceutics·Erik SöderlindJennifer J Sheng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Hussien AllabounWafa'a Y AlMomani
© 2022 Meta ULC. All rights reserved