Surfactant phospholipid changes after antigen challenge: a role for phosphatidylglycerol in dysfunction

American Journal of Physiology. Lung Cellular and Molecular Physiology
R Duncan HiteDavid A Bass

Abstract

In asthma, inflammation-mediated surfactant dysfunction contributes to increased airway resistance, but the mechanisms for dysfunction are not understood. To test mechanisms that alter surfactant function, atopic asthmatics underwent endobronchial antigen challenge and bronchoalveolar lavage (BAL). BAL fluids were sequentially separated into cells, surfactant, and supernatant, and multiple end points were analyzed. Each end point's unique relationship to surfactant dysfunction was determined. Our results demonstrate that minimum surface tension (gamma(min)) of surfactant after antigen challenge was significantly increased with a spectrum of responses that included dysfunction in 6 of 13 asthmatics. Antigen challenge significantly altered the partitioning of surfactant phospholipid measured as a decreased ratio of large surfactant aggregates (LA) to small surfactant aggregates (SA), LA/SA ratio. Phosphatidylglycerol (PG) was significantly reduced in the LA of the dysfunctional asthmatic BALs. There was a corresponding significant increase in the ratio of phosphatidylcholine to PG, which strongly correlated with both increased gamma(min) and decreased LA/SA. Altered surfactant phospholipid properties correlated with surfactant dy...Continue Reading

References

Aug 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·G Enhorning
Dec 1, 1991·The Journal of Clinical Investigation·T J GregoryT M Hyers
Jan 1, 1991·Chemistry and Physics of Lipids·A R VenkitaramanR H Notter
Jan 1, 1970·Respiration Physiology·P T MacklemJ C Hogg
Mar 1, 1994·American Journal of Respiratory and Critical Care Medicine·M H ShinR M Naclerio
Jun 1, 1993·Journal of Applied Physiology·G Enhorning, B A Holm
Dec 1, 1995·American Journal of Respiratory and Critical Care Medicine·R A VeldhuizenJ F Lewis
Nov 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M LiuG Enhorning
May 1, 1996·The Journal of Experimental Medicine·F H ChiltonM C Liu
Feb 1, 1997·American Journal of Respiratory and Critical Care Medicine·D L BowtonD A Bass
Apr 16, 1998·Biochemical and Biophysical Research Communications·R DhandN J Gross
Nov 14, 1998·Biochimica Et Biophysica Acta·R VeldhuizenF Possmayer
Feb 23, 1999·Biochemistry·K Shinozaki, M Waite
Jun 3, 1999·American Journal of Respiratory and Critical Care Medicine·J M HohlfeldN Krug
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·N N Jarjour, G Enhorning
Feb 9, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·E L HeeleyA D Postle
Jun 29, 2000·American Journal of Respiratory Cell and Molecular Biology·M C SeedsD A Bass
Jun 12, 2003·The European Respiratory Journal·K S BabuJ H Conway
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER
Nov 2, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·R Duncan HiteB Moseley Waite

❮ Previous
Next ❯

Citations

Nov 8, 2007·Respirology : Official Journal of the Asian Pacific Society of Respirology·Miki AboTsutomu Kobayashi
Sep 3, 2008·Journal of Veterinary Internal Medicine·U ChristmannR D Hite
Feb 5, 2009·Journal of Veterinary Internal Medicine·U ChristmannR D Hite
Aug 4, 2009·Journal of Veterinary Internal Medicine·U ChristmannV A Buechner-Maxwell
Nov 1, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·R Duncan HiteMichael C Seeds
Jun 6, 2009·American Journal of Respiratory Cell and Molecular Biology·Spyros SpyridakisDia Galanopoulou
Apr 7, 2010·American Journal of Veterinary Research·Undine ChristmannVirginia A Buechner-Maxwell
Jan 15, 2016·Experimental Lung Research·Diana BusleyIsabel Hennig-Pauka
Mar 16, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S N GeorasV Natarajan
May 20, 2014·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Panneerselvam VijayarajVasanthi Nachiappan
Nov 1, 2006·Allergology International : Official Journal of the Japanese Society of Allergology·Wayne Mitzner
Oct 16, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Veit J ErpenbeckJens M Hohlfeld
Mar 11, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Charles G Cochrane
Jan 9, 2010·Journal of Applied Physiology·Ann-Charlotte AlmstrandAnna-Carin Olin
Jul 23, 2020·Frontiers in Physiology·Bradford J SmithJason H T Bates
Apr 3, 2019·Frontiers in Immunology·Belén García-FojedaCristina Casals

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.