Surfactant properties differentially influence intravascular gas embolism mechanics.

Annals of Biomedical Engineering
T N SwaminathanDavid M Eckmann

Abstract

Gas bubble motion in a blood vessel causes temporal and spatial gradients of shear stress at the cell surface lining the vessel wall as the bubble approaches the cell, moves over it and passes it by. Rapid reversals occur in the sign of the shear stress imparted to the cell surface during this motion. These may result in injury to the cell. The presence of a soluble surfactant in the bulk medium reduces the level of the shear stress gradients imparted to the cell surface as compared to an equivalent surfactant-free system and is an important therapeutic aid. This is particularly true for a very small vessel. In this study, we analyze various physical and chemical properties of any given soluble surfactant to ascertain the relative significance of the property of the surfactant on the reduction in the level of the shear stress gradients imparted to the cell surface in such a vessel. While adsorption, desorption, and maximum possible monolayer interface surfactant concentration significantly impact the shear stress levels, physical properties such as the bulk or surface diffusivity do not appear to have large effects. At a given diameter, surfactants with k(a)/(k(d)d>O(10)⁻⁵ and Γ(∞)/C(0)d>9.5 x 10⁻⁴ are noted to be preferable fr...Continue Reading

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Citations

Jun 3, 2011·American Journal of Physiology. Cell Physiology·Peter SobolewskiDavid M Eckmann
Sep 27, 2012·Microvascular Research·Ivo P Torres FilhoBruce D Spiess

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