PMID: 8981524Nov 1, 1996Paper

Surfactant protein A and lamellar bodies: a homologous secretory function of peritoneum, synovium, and lung

Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis
J W Dobbie

Abstract

To review recent discoveries on the existence of lamellar body secreting cells in extrapulmonary sites with respect to their constitution as a previously unrecognized coherent biological system and to evaluate the role of mesothelial research in peritoneal dialysis in initiating this new field of medical research. Studies in the literature on the production and metabolism of pulmonary surfactant with respect to lamellar bodies and surfactant protein A (SP-A). Published investigations on the identification of lamellar bodies and SP-A in extrapulmonary sites and their possible role in systemic expression of autoimmune disorders. It is now established that lamellar bodies of identical periodicity and ultrastructural geometry are present in lung (type II pneumocytes), serosal mesothelium (peritoneum, pleura, and pericardium), and joints (type A and type B synoviocytes). Not only pulmonary lamellar bodies but those at extrapulmonary sites are found in association with SP-A, while SP-A or SP-A-like proteins are present in measurable quantities in normal serosal fluids. These findings have disclosed totally new avenues of research into multisystem disorders, where for the first time an organelle and associated protein provide a link b...Continue Reading

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