Surfactant protein A suppresses lipopolysaccharide-induced IL-10 production by murine macrophages

The Journal of Immunology : Official Journal of the American Association of Immunologists
L SalezM Chignard

Abstract

Upon LPS exposure, mononuclear phagocytes produce TNF-alpha and IL-10, two cytokines with pro- and anti-inflammatory activities, respectively. We previously described that murine resident alveolar macrophages, which play a central role in the immunosurveillance of the lung alveoli, do not synthesize IL-10 in vivo or in vitro when exposed to LPS. In the present report we demonstrate that during lung inflammation induced by the intranasal administration of LPS, bronchoalveolar cells collected between days 3 and 5 are able to synthesize IL-10 when exposed to LPS. We also show that depletion of resident alveolar macrophages by an intratracheal instillation of liposome-encapsulated clodronate is followed by subsequent replenishment of the airspaces by mononuclear phagocytes. This is accompanied by the transient competence of cells for IL-10 production. The cell capacity to produce IL-10 is evident up to 3 days and then decreases. This led us to hypothesize that the alveolar environment contains a down-regulator of LPS-induced IL-10 synthesis by recently emigrating mononuclear phagocytes. We show that the surfactant protein A, an airspace protein that has known immunomodulatory activities, dramatically inhibits LPS-induced IL-10 form...Continue Reading

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Citations

Jun 11, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Loïc GuillotMustapha Si-Tahar
Feb 21, 2003·American Journal of Respiratory Cell and Molecular Biology·Sophie ChabotMichel Chignard
Aug 23, 2005·Infection and Immunity·Viviane BalloyMichel Chignard
May 20, 2005·Cell and Tissue Research·Takuma SaitoMakoto Naito
Apr 10, 2009·Inflammation·Florian KollertAntje Prasse
Sep 9, 2010·Cell and Tissue Research·David SchnebergerBaljit Singh
Oct 12, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Samuel HawgoodFrancis R Poulain
Dec 20, 2014·Annals of the American Thoracic Society·Wei Duan, Michael Croft
Mar 29, 2019·Intensive Care Medicine Experimental·Frank Silva BezerraAkinori Cardozo Nagato
Feb 25, 2009·Inhalation Toxicology·Hong-li ChenXu-jun Qin
Jul 10, 2004·Acta Anaesthesiologica Scandinavica·M P YeagerA U Munck
Sep 21, 2004·Shock·Rachel G KhadarooOri D Rotstein
Aug 30, 2003·The Journal of Biological Chemistry·Masahito HashimotoTomohiko Ogawa

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