Surfactant protein B and RAGE increases in the plasma during cardiopulmonary bypass: a pilot study

The European Respiratory Journal
Piergiuseppe AgostoniE Sisillo

Abstract

Surfactant derived protein B (SPB) and plasma receptor for advanced glycation end products (RAGE) have been proposed as markers of lung injury. The former is produced specifically by pneumocytes while RAGE production is present in several body tissues. Cardiopulmonary bypass (CPB) generates a transient lung injury. We measured SPB and RAGE in plasma before surgery and after CPB, as well as 24 h and 48 h later. We analysed plasma samples from 20 subjects scheduled for elective coronary artery bypass grafting. We performed a quantitative analysis of plasma levels of RAGE and SPB mature form (8 kDa) by ELISA and a semi-quantitative analysis of SPB immature form (~ 40 kDa) by Western blotting. Surgery procedures were uneventful. After CPB RAGE median (75th-25th interquartile difference) increased from 633 (539) pg·mL⁻¹ to 1,362 (557) pg·mL⁻¹ (p < 0.01), while mature SPB increased from 5,587 (3,089) ng·mL⁻¹ to 20,307 (19,873) ng·mL⁻¹ (p < 0.01). RAGE and mature SPB returned to normal values within 48 h. This behaviour was confirmed when RAGE and SPB were normalised for protein content. Parallel changes were observed for immature SPB. Plasma RAGE and SPBs are sensitive and rapid markers of lung distress.

Citations

May 24, 2012·Critical Care : the Official Journal of the Critical Care Forum·XiWang LiuXiangMing Fang
Apr 27, 2013·Respiratory Physiology & Neurobiology·Piergiuseppe AgostoniGianfranco Parati
Mar 8, 2016·Research in Cardiovascular Medicine·Antonio NennaCristiano Spadaccio
Mar 13, 2014·Proteomics. Clinical Applications·Elizabeth V NguyenDavid R Goodlett
Oct 4, 2013·Mediators of Inflammation·Benedict C Creagh-BrownAnne Burke-Gaffney
Apr 14, 2015·Disease Markers·Gerwin Erik Engels, Willem van Oeveren
Dec 17, 2014·PloS One·Paola GargiuloPiergiuseppe Agostoni
Jul 15, 2016·International Journal of Cardiology·Cristina Banfi, Piergiuseppe Agostoni
May 16, 2018·Respiration; International Review of Thoracic Diseases·Nicolas KahnMichael Kreuter
Oct 15, 2019·Critical Care Medicine·Yiorgos Alexandros CavayasAndré Y Denault
Sep 30, 2014·The International Journal of Artificial Organs·Gerwin E EngelsGiuseppe Faggian

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