Surfactant protein D levels in umbilical cord blood and capillary blood of premature infants. The influence of perinatal factors

Pediatric Research
Marianne DahlPekka Olavi Juvonen

Abstract

Surfactant protein D (SP-D) is a collectin that plays an important role in the innate immune system and takes part in the surfactant homeostasis by regulating the surfactant pool size. The aims of this study were to investigate the values of SP-D in umbilical cord blood and capillary blood of premature infants and to relate the levels to perinatal conditions. A total of 254 premature infants were enrolled in the present study. Umbilical cord blood was drawn at the time of birth and capillary blood at regular intervals throughout the admission. The concentration of SP-D in umbilical cord blood and capillary blood was measured using ELISA technique. The median concentration of SP-D in umbilical cord blood was twice as high as in mature infants, 769 ng/mL (range 140-2,551), with lowest values in infants with intrauterine growth retardation (IUGR) and rupture of membranes (ROM). The median concentration of SP-D in capillary blood day 1 was 1,466 ng/mL (range 410-5,051 ng/mL), with lowest values in infants born with ROM and delivered vaginally. High SP-D levels in umbilical cord blood and capillary blood on day 1 were found to be more likely in infants in need for respiratory support or surfactant treatment and susceptibility to inf...Continue Reading

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Citations

May 25, 2012·American Journal of Clinical Dermatology·Hayam Abdel Samie AiadShaymaa Abd El-Aziz Othman
Jul 13, 2014·The Journal of Pediatrics·Grith Lykke SorensenSteffen Husby
Jun 5, 2007·Immunobiology·Grith Lykke SorensenUffe Holmskov
Feb 24, 2018·Frontiers in Medicine·Grith L Sorensen
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Apr 2, 2021·Pediatric Research·Nagwan Yossery SalehAsmaa Abdel Sameea Mahmoud
Apr 11, 2020·Chest·Mary K DahmerUNKNOWN BALI and RESTORE Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network

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