PMID: 15220777Jun 29, 2004Paper

Surfactant reduction in embolism bubble adhesion and endothelial damage

Anesthesiology
Akira SuzukiDavid M Eckmann

Abstract

Surfactants may reduce the adhesion force holding bubbles to the vessel wall in gas embolism. The authors measured bubble adhesion force using excised microvessels. They assessed endothelial damage by measuring vessel reactivity and with microscopy. Microbubbles injected into arterioles resided for 5, 10, or 30 min, with intact or damaged endothelium. Perfusion was with rat serum alone (control) or with 1% Perftoran (OJSC SPC Perftoran, Moscow, Russia) or 1% Pluronic F-127 (Molecular Probes, Eugene, OR) added. Pressure across the bubble, bubble length, and bubble diameter were measured, and adhesion force per unit surface area, K = deltaPD/4 l, was calculated. Vessel reactivity was assessed using topical application of phenylephrine and acetylcholine. With the endothelium intact, K was higher in controls than with Perftoran at 10 and 30 min or Pluronic F-127 at 10 min (P < 0.05). With surfactant added after air perfusion to damage the endothelium, K was lower (P < 0.05) at all times for both Perftoran and Pluronic F-127. With surfactant in the perfusate before air perfusion, K was lower at 10 and 30 min for Perftoran and at 10 min for Pluronic F-127 than for controls (P < 0.05). Phenylephrine-induced vasoconstriction was identi...Continue Reading

References

Oct 12, 1999·Journal of Applied Physiology·A B Branger, D M Eckmann
Feb 17, 2000·The New England Journal of Medicine·C M Muth, E S Shank
Aug 9, 2001·Seminars in Thoracic and Cardiovascular Surgery·R Engelman
Aug 9, 2001·Seminars in Thoracic and Cardiovascular Surgery·R A BakerJ L Knight
Aug 9, 2001·Seminars in Thoracic and Cardiovascular Surgery·J W HammonD M Moody
Apr 20, 2002·Anesthesiology·Annette B Branger, David M Eckmann
Feb 7, 2003·Journal of Applied Physiology·David M Eckmann, Vladimir N Lomivorotov
Jul 29, 2003·Anesthesiology·Akira Suzuki, David M Eckmann
Sep 10, 2003·Anesthesiology·Naomi Sta Maria, David M Eckmann
Dec 27, 2003·Anesthesiology·David M Eckmann, Scott L Diamond

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Citations

Jul 14, 2010·Annals of Biomedical Engineering·T N SwaminathanD M Eckmann
Mar 23, 2010·Journal of Fluid Mechanics·T N SwaminathanD M Eckmann
Jan 21, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Joshua W LampeDavid M Eckmann
Sep 21, 2011·Integrative Biology : Quantitative Biosciences From Nano to Macro·Alexandra L KlingerDavid M Eckmann
Mar 28, 2008·Seminars in Dialysis·Michal BarakYeshayahu Katz
Jul 31, 2009·Journal of Biomechanical Engineering·K MukundakrishnanD M Eckmann
Feb 7, 2012·Aviation, Space, and Environmental Medicine·Karthik MukundakrishnanDavid M Eckmann
Apr 19, 2007·Neurological Research·Eri Fukaya, Harriet W Hopf
Jul 6, 2005·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·David M EckmannMin Li
Nov 24, 2006·Anesthesiology·David M Eckmann, Stephen C Armstead
Nov 25, 2006·Annals of the New York Academy of Sciences·David M EckmannPortonovo S Ayyaswamy
Sep 27, 2012·Microvascular Research·Ivo P Torres FilhoBruce D Spiess
Feb 19, 2014·Advances in Colloid and Interface Science·Virginie PapadopoulouThodoris D Karapantsios
Oct 21, 2005·Chest·Michal Barak, Yeshayahu Katz
Jun 29, 2017·Computer Methods in Biomechanics and Biomedical Engineering·Adnan QamarJoseph L Bull
Oct 15, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Karthik MukundakrishnanDavid M Eckmann
Dec 21, 2011·The International Journal of Artificial Organs·Song LouCun Long
Apr 7, 2020·Medicine and Science in Sports and Exercise·Dirk MayerKatja Bettina Ferenz
Mar 26, 2005·Journal of Applied Physiology·Andrés J CalderónJoseph L Bull
Jun 7, 2008·Experimental Biology and Medicine·Duska GlavasZeljko Dujic
Apr 8, 2017·Frontiers in Physiology·Kun ZhangWeigang Xu
Oct 18, 2013·Experimental Biology and Medicine·Alexandra L KlingerDavid M Eckmann

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