Surfactant regulates pulmonary fluid balance in reptiles

The American Journal of Physiology
S OrgeigJ K Herman

Abstract

Reptilian lungs are potentially susceptible to fluid disturbances because they have very high pulmonary fluid filtration rates. In mammals, pulmonary surfactant protects the lung from developing alveolar edema. Reptiles also have an order of magnitude more surfactant per square centimeter of respiratory surface area compared with mammals. We investigated the role of reptilian surfactant 1) in the entry of vascularly derived fluid into the alveolar space of the isolated perfused lizard (Pogona vitticeps) lung and 2) in the removal of accumulated fluid from the alveolar space of the isolated perfused turtle (Trachemys scripta) lung by both the pulmonary venous and lymphatic circulations. The flux of fluorescent (fluorescein isothiocyanate) inulin from the vasculature into the alveolar compartment increased 60% after the removal of surfactant, but capillary fluid filtration over a 10-min period was not affected. Surfactant removal decreased alveolar inulin clearance by both the pulmonary venous circulation and the pulmonary lymphatic system approximately 1.5- and 3-fold, respectively. In reptiles, fluid flux from capillary to air space must occur indirectly via the interstitium. In the absence of surfactant, this may result in int...Continue Reading

References

May 1, 1992·The American Review of Respiratory Disease·M IkegamiJ F Lewis
Jan 1, 1985·Journal of Applied Physiology·G F Nieman, C E Bredenberg
Oct 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·K C Beck, S J Lai-Fook
Jun 1, 1983·The Journal of Surgical Research·C E BredenbergG F Nieman
Oct 1, 1993·Respiration Physiology·C B DanielsT E Nicholas

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Citations

Mar 16, 2006·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·W Jeffrey WeidnerJ David Furlow

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