Surfactant replacement therapy in combination with different non-invasive ventilation techniques in spontaneously-breathing, surfactant-depleted adult rabbits

PloS One
Francesca RicciFabrizio Salomone

Abstract

Nasal intermittent positive pressure ventilation (NIPPV) holds great potential as a primary ventilation support method for Respiratory Distress Syndrome (RDS). The use of NIPPV may also be of great value combined with minimally invasive surfactant delivery. Our aim was to implement an in vivo model of RDS, which can be managed with different non-invasive ventilation (NIV) strategies, including non-synchronized NIPPV, synchronized NIPPV (SNIPPV), and nasal continuous positive airway pressure (NCPAP). Forty-two surfactant-depleted adult rabbits were allocated in six different groups: three groups of animals were treated with only NIV for three hours (NIPPV, SNIPPV, and NCPAP groups), while three other groups were treated with surfactant (SF) followed by NIV (NIPPV+SF, SNIPPV+SF, and NCPAP+SF groups). Arterial gas exchange, ventilation indices, and dynamic compliance were assessed. Post-mortem the lungs were sampled for histological evaluation. Surfactant depletion was successfully achieved by repeated broncho-alveolar lavages (BALs). After BALs, all animals developed a moderate respiratory distress, which could not be reverted by merely applying NIV. Conversely, surfactant administration followed by NIV induced a rapid improvemen...Continue Reading

References

Feb 16, 1967·The New England Journal of Medicine·W H NorthwayD Y Porter
Nov 14, 1997·American Journal of Respiratory and Critical Care Medicine·J D MrozekM C Mammel
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·A H Jobe, E Bancalari
Jun 30, 2005·Biology of the Neonate·L J I ZimmermannV P Carnielli
May 15, 2007·Current Opinion in Pediatrics·Jan MazelaNeil N Finer
Aug 19, 2007·Journal of Perinatology : Official Journal of the California Perinatal Association·V BhandariN L Brodsky
Sep 30, 2009·Respiration; International Review of Thoracic Diseases·Don HayesHubert O Ballard
May 12, 2010·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Neil N FinerRobert Segal
Jul 9, 2010·Pediatric Research·Kari D RobertsMark C Mammel
Aug 25, 2010·Pediatrics·Barbara J StollUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Sep 30, 2010·European Journal of Pediatrics·Jan Mazela, Richard A Polin
Oct 7, 2010·Pediatric Research·Hung-Yang ChangEduardo Bancalari
Oct 26, 2010·Archives of Disease in Childhood. Fetal and Neonatal Edition·Peter A DargavilleAntonio G De Paoli
Feb 22, 2011·Archives of Disease in Childhood. Fetal and Neonatal Edition·L S OwenP G Davis
Oct 26, 2011·Pediatrics·Michael S DunnUNKNOWN Vermont Oxford Network DRM Study Group
Jan 30, 2013·Respiratory Care·Brian K WalshUNKNOWN American Association for Respiratory Care
Oct 17, 2014·Archives of Disease in Childhood. Fetal and Neonatal Edition·Camilla GizziRocco Agostino
Feb 29, 2016·Seminars in Fetal & Neonatal Medicine·Louise S Owen, Brett J Manley
Jul 2, 2016·Pediatrics·Peter A DargavilleUNKNOWN Australian and New Zealand Neonatal Network

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BETA
lavages
lavage

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GraphPad

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