Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 5: intercellular junctions and contacts between germs cells and Sertoli cells and their regulatory interactions, testicular cholesterol, and genes/proteins associated with more than one germ cell generation

Microscopy Research and Technique
Louis HermoCharles E Smith

Abstract

In the testis, cell adhesion and junctional molecules permit specific interactions and intracellular communication between germ and Sertoli cells and apposed Sertoli cells. Among the many adhesion family of proteins, NCAM, nectin and nectin-like, catenins, and cadherens will be discussed, along with gap junctions between germ and Sertoli cells and the many members of the connexin family. The blood-testis barrier separates the haploid spermatids from blood borne elements. In the barrier, the intercellular junctions consist of many proteins such as occludin, tricellulin, and claudins. Changes in the expression of cell adhesion molecules are also an essential part of the mechanism that allows germ cells to move from the basal compartment of the seminiferous tubule to the adluminal compartment thus crossing the blood-testis barrier and well-defined proteins have been shown to assist in this process. Several structural components show interactions between germ cells to Sertoli cells such as the ectoplasmic specialization which are more closely related to Sertoli cells and tubulobulbar complexes that are processes of elongating spermatids embedded into Sertoli cells. Germ cells also modify several Sertoli functions and this also appe...Continue Reading

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Citations

Nov 3, 2010·Asian Journal of Andrology·Andrew T ReidBrett Nixon
Jan 5, 2013·Human Reproduction Update·Xiang XiaoC Yan Cheng
Oct 28, 2016·PloS One·Anke WittmannThomas Floss
May 22, 2019·American Journal of Physiology. Endocrinology and Metabolism·Ming YanC Yan Cheng
Aug 8, 2021·International Journal of Molecular Sciences·Kristina RodeRalph Brehm

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