Surgery Alone Versus Surgery Followed by Chemotherapy and Radiotherapy in Resected Extrahepatic Bile Duct Cancer: Treatment Outcome Analysis of 336 Patients

Cancer Research and Treatment : Official Journal of Korean Cancer Association
Jung Ho ImKyung Ran Park

Abstract

This study analyzed the outcomes of patients with resected extrahepatic bile duct cancer (EHBDC) in order to clarify the role of adjuvant treatments in these patients. A total of 336 patients with EHBDC who underwent curative resection between 2001 and 2010 were analyzed retrospectively. The treatment types were as follows: surgery alone (n=168), surgery with chemotherapy (CTx, n=90), surgery with radiotherapy (RT) alone (n=29), and surgery with chemoradiotherapy (CRT, n=49). The median follow-up period was 63 months. The 5-year rates of locoregional failure-free survival (LRFFS), distant metastasis-free survival (DMFS), progression-free survival (PFS), and overall survival (OS) for all patients were 56.5%, 59.7%, 36.6%, and 42.0%, respectively. In multivariate analysis, surgery with RT and CRT was a significant prognostic factor for LRFFS, and surgery with CTx was a significant prognostic factor for DMFS, and surgery with CTx, RT, and CRT was a significant prognostic factor for PFS (p < 0.05). Surgery with CTx and CRT showed association with superior OS (p < 0.05), and surgery with RT had marginal significance (p=0.078). In multivariate analysis of the R1 resection patients, surgery with CRT showed significant association with...Continue Reading

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Citations

Mar 12, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rachna T ShroffShishir K Maithel
Jul 8, 2020·Journal of Zhejiang University. Science. B·Xin-Qi ShiAi-Lin Li
Jun 27, 2019·World Journal of Clinical Cases·Taeryool KooKyubo Kim
Nov 25, 2016·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Stefano AndrianelloRoberto Salvia
Apr 28, 2017·Cancer Chemotherapy and Pharmacology·Sang-Won KimDukyong Yoon
Jan 28, 2020·Cancer Treatment Reviews·Angela LamarcaJuan W Valle
Oct 27, 2020·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Ikuma ShioiDaisuke Aizawa
Jan 1, 2021·Frontiers in Oncology·Eleni GkikaThomas B Brunner
Sep 22, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·UNKNOWN Cholangiocarcinoma Working Group
Mar 30, 2021·Frontiers in Oncology·Xiuqiong ChenYanmei Zou
May 25, 2021·International Journal of Radiation Oncology, Biology, Physics·Won Ick ChangEui Kyu Chie
Dec 23, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Xianxian YaoNobutaka Hanagata

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Methods Mentioned

BETA
surgical resection
dissection

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