Surgery and additional protontherapy for treatment of invasive and recurrent squamous cell carcinomas: technique and preliminary results

Journal français d'ophtalmologie
J-P CaujolleP Gastaud

Abstract

Invasive squamous cell carcinomas are uncommon neoplasias with high recurrence and mortality rates. The improvement of tumoral control requires additional treatments such as cryotherapy, topical chemotherapy, and radiotherapy. We present the technique and preliminary results of associating treatment with surgery and proton beam therapy for recurrent and invasive squamous cell carcinomas. From June 2001 to September 2008, 15 patients were treated in our ocular oncologic center for squamous cell carcinomas either with recurrences or with invaded resection margins. The treatment combined new surgical resection with protontherapy. Specific improvements in proton beam therapy have been made at the Nice Cyclotron to adapt the treatment to conjunctival tumors. Proton beam carving consists in using a specific device to treat the thickness of the whole lesion site and the adjacent conjunctiva and to spare the surrounding healthy structures. Patients were staged according to the TNM classification of malignant tumors in T2: 3; T3: 5; T4: 7. Mean follow-up was 39.1 months (range, 6-90 months). Our 15 patients included 12 males and three females. Left eyes were involved in eight cases. The mean age at first consultation was 63.7 years (ran...Continue Reading

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Citations

Jun 27, 2012·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·N ArendC Hintschich
Oct 29, 2015·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·P JardelJ Thariat
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Jul 25, 2013·Acta Ophthalmologica·Celia Maschi-CaylaJean P Caujolle
Dec 16, 2018·American Journal of Ophthalmology·Alexandra SantoniJean-Pierre Caujolle

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