Surgery and hormone therapy trends in octogenarians with invasive breast cancer

American Journal of Surgery
Olga KantorKatharine Yao

Abstract

There has been a trend toward minimizing surgery in elderly women with estrogen receptor-positive (ER+) breast cancer. Using the National Cancer Data Base, we selected 95,357 women ≥80 years with invasive, ER+ breast cancer. Chi-square test and logistic regression were used to analyze trends in surgery and hormone therapy. From 2004 to 2012, 90% of women were treated with surgery first and 10% were treated with primary nonoperative management. Of those undergoing nonoperative management, 72% received endocrine therapy and 27% had no treatment. The rate of primary nonoperative treatment doubled from 7% in 2004 to 14% in 2012. Multivariate logistic regression adjusted for patient, facility, and tumor factors identified more advanced clinical stage, older age, African-American race, and treatment at Academic facilities as independent predictors of receiving primary nonsurgical management. There has been an increase over time in primary nonoperative management of ER+ breast cancer in octogenarians.

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Citations

Sep 20, 2016·American Journal of Surgery·Erica PettkeAye Moe Thu Ma
Dec 15, 2017·Current Geriatrics Reports·R M C PeppingN A de Glas
Apr 24, 2019·Surgery Today·Yoshinari OgawaYuko Tsuboguchi
Jun 27, 2019·Current Oncology Reports·Julia FrebaultAmanda L Kong
Mar 13, 2021·The British Journal of Surgery·Y JauhariD A Cromwell
Jul 19, 2021·The Breast : Official Journal of the European Society of Mastology·Abdulla Al-RashdanLisa Barbera

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