Surgery and prognostic factors for gastric stromal tumor

World Journal of Surgery
S J Kwon, Korean Gastric Cancer Study Group

Abstract

Morphologic studies of gastric stromal tumors (GSTs) indicate that mitotic counts (MCs) and tumor size are major discriminants predictive of biologic behavior. The purpose of this study is to improve the understanding of GST behavior, including the prognostic factors and surgical treatment of GSTs. A retrospective analysis (1990--1997) of the clinical course for 116 patients with GSTs was completed, with a median follow-up of 43 months. Tumors were categorized as malignant GSTs (n = 17) when the MC was > 5/50 high-power fields (HPF) and the size > 5 cm or as benign GSTs (n = 99) when the MC was < or = 5/50 HPF and the size < or = 5 cm, MC < or = 5/50 HPF and size > 5 cm, or MC > 5/50 HPF and size < or = 5 cm. None of 99 benign tumors recurred or metastasized, whereas 7 of 17 malignant tumors recurred. MCs had a close correlation with tumor size. Immunohistochemical studies using CD34, smooth muscle actin, S-100 protein, and synaptophysin have shown positive rates of 61%, 33%, 14%, and 3%, respectively. Smooth muscle actin reactivity was more common in the benign tumors (p = 0.046) and synaptophysin reactivity in the malignant tumors (p = 0.010). Univariate analysis showed that the following clinicopathologic factors were potent...Continue Reading

Citations

Aug 9, 2005·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yoshihide Otani, Masaki Kitajima
Jan 9, 2009·Journal of Gastrointestinal Cancer·Eiji OkiMichio Yoshida
Jul 2, 2003·Molecular Immunology·Walid SalamounDany Abi Gerges
Apr 24, 2007·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Roberta GelminiPier Franco Conte
May 23, 2008·Journal of Cardiothoracic Surgery·S Papaspyros, K Papagiannopoulos
Mar 20, 2008·World Journal of Gastroenterology : WJG·Mou-Bin LinQian-Jian Qian
Feb 6, 2013·World Journal of Gastroenterology : WJG·Borislav BelevJasminka Jakić Razumović
Jan 16, 2013·JSLS : Journal of the Society of Laparoendoscopic Surgeons·Norman Oneil Machado
May 22, 2007·International Journal of Surgery·Giuseppe CavallaroGiorgio De Toma
Dec 20, 2005·Journal of Korean Medical Science·Kyoung-Mee KimUNKNOWN Korean Gastrointestinal Pathology Study Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Surgical Clinics of North America
Chirag Dholakia, Jon Gould
Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
C Söderman, A Uribe
Journal of Laparoendoscopic Surgery
B M SmithT E Lobe
© 2021 Meta ULC. All rights reserved