Surgery for "Long-term epilepsy associated tumors (LEATs)": Seizure outcome and its predictors

Clinical Neurology and Neurosurgery
Ashalatha RadhakrishnanSanjeev V Thomas

Abstract

"Long-term epilepsy associated tumors (LEATs)" by definition are tumors primarily causing drug-resistant seizures for two years or more. They include low-grade glial and glioneuronal tumors with normal life expectancy. We studied a large cohort of patients with LEATs who underwent surgery through our epilepsy program. From 1998-2011, 105 patients with LEATs underwent surgery in our center. We utilized their data archived in a prospective registry to evaluate their electro-clinical-imaging characteristics affecting the long-term seizure outcome. Of 105 patients (age 3-50 years), mean age at surgery was 20 years and mean pre-surgical duration of epilepsy was 10.9 years. 66 (62.8%) had secondary generalized seizures. 82 had temporal tumors, 23 had extra temporal (13 frontal, 3 parietal, 2 occipital and 5 multilobar lesions) and four had associated hippocampal sclerosis. The interictal discharges and ictal onset were concordant to the lesion in 82 (78%) and 98 (93%) patients respectively. Lesionectomy and/or adjoining corticectomy or temporal lobectomy was done. Ganglioglioma was the most dominant pathological substrate in 61 (58%). During a mean follow-up of 7.5 years (range 3-16 years), 78/105 (74.2%) were seizure-free and 45 (57...Continue Reading

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Citations

Sep 4, 2018·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Chinmay NageshChandrasekharan Kesavadas
Aug 9, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Marta MaschioUNKNOWN Brain Tumor-related Epilepsy study group of Italian League Against Epilepsy (LICE)
Aug 15, 2017·Epilepsia·Marco GiulioniUNKNOWN Commission for Epilepsy Surgery of the Italian League Against Epilepsy
Nov 25, 2020·Neurosurgery·Diana L Thomas, Christopher R Pierson

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