PMID: 2870756Apr 1, 1986Paper

Surgery for peptic ulceration associated with hypergastrinaemia

The British Journal of Surgery
C G ClarkP B Boulos


Between 1971 and 1983, 31 males and 13 females were found to have peptic ulceration associated with hypergastrinaemia. An antral G-cell lesion was present in 11 (25 per cent) and a gastrinoma in 14 (32 per cent). There were 11 patients with multiple endocrine adenomatosis (MEA) (25 per cent) and 4 (9 per cent) with primary hyperparathyroidism. Four patients (9 per cent) were unclassified. Length of history and level of gastrin did not differentiate between the groups and an average of 2.5 operations was performed per patient, while the overall mortality was 27.3 per cent. The patients with G-cell lesions were significantly younger than all the other groups (P less than 0.01). Partial gastrectomy adequately treated G-cell hyperplasia. Total gastrectomy was required to treat pancreatic gastrinomata but additional pancreatic resection did not improve the outcome. In MEA, parathyroidectomy did not influence the treatment of a gastrinoma. This is the first recorded experience of surgery for hypergastrinaemia in the United Kingdom and the outcome of such a retrospective study may be a guide to the future management of these conditions.


Jul 1, 1979·Clinics in Endocrinology and Metabolism·F Stadil, J G Stage
Sep 20, 1979·World Journal of Surgery·H D BeckerA Schafmayer
Sep 20, 1979·World Journal of Surgery·S BonfilsJ Gratton
Jan 1, 1985·American Journal of Surgery·B E Stabile, E Passaro
Mar 1, 1985·Scandinavian Journal of Gastroenterology·L Bardram, J G Stage
Oct 1, 1967·The British Journal of Surgery·D JohnstonH L Duthie
Jan 1, 1983·American Journal of Surgery·B E StabileE Passaro
Oct 1, 1983·Annals of Surgery·C W DeveneyL W Way
Aug 1, 1984·World Journal of Surgery·R M ZOLLINGERJ Sparks
Oct 1, 1984·Annals of Surgery·J W HarmonR T Jensen
Jan 1, 1983·Annals of Internal Medicine·R T JensenM J Collen
Nov 1, 1984·Postgraduate Medical Journal·J Hansky
Mar 1, 1982·American Journal of Surgery·S R Friesen
Nov 1, 1984·The American Journal of Surgical Pathology·K J LewinJ Walsh
Oct 1, 1983·Scottish Medical Journal·J N PrimroseK D Buchanan
Apr 14, 1983·The New England Journal of Medicine·R T JensenJ D Gardner
May 1, 1983·Annals of Surgery·J C ThompsonC M Townsend
Mar 1, 1982·Missouri Medicine·J B Marshall
Mar 1, 1980·Annals of Surgery·F KeuppensM C Woussen-Colle

Related Concepts

Related Feeds

Adenoma, Islet Cell

Islet Cell Adenoma arises in the islet cells, which are insulin producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on Islet Cell Adenoma here.

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.