Surgery for synchronous and metachronous single-organ metastasis of pancreatic cancer: a SEER database analysis and systematic literature review

Scientific Reports
Qiaofei LiuJorg Kleeff

Abstract

Surgery for metastatic pancreatic cancer remains controversial as the survival benefit is questionable. The aim of the present study was to analyze the survival of these patients using data extracted from the surveillance, epidemiology, and end results (SEER) program database. Further, studies on resection for metastatic disease to the lung were systematically reviewed. A total of 11,541 cases with synchronous distant metastasis were analyzed. The median survival of single-organ metastasis was better than of multi-organ metastasis (single-organ 4.0 ± 0.07 months, two-organs 3.0 ± 0.13 months, three/four-organs 2.0 ± 0.19 months; p < 0.0001). Single organ lung metastasis had longer median survival times compared to the other sites (lung 6.0 ± 0.32 months, HR 0.87, 95% CI 0.78-0.97; p = 0.013). Resection of the primary tumor was associated with longer survival in synchronous single-organ metastasis to the lung compared to no resection (14.0 ± 1.93 months vs 6.0 ± 0.31 months, p < 0.0001). A systematic literature review identified 79 cases of metachronous lung metastasis with a survival of 120.0 ± 6.32 months and 83.0 ± 24.84 months following resection of the primary tumor and metastasis, respectively. Lower TNM staging, longer in...Continue Reading

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Citations

May 20, 2020·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·J G D'HaeseJ Werner
Aug 6, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Francesco GuerraDiego Coletta
May 1, 2021·Experimental Hematology & Oncology·Chao Wang, Daya Luo
Jun 2, 2021·Seminars in Oncology·Johannes KloseJörg Kleeff
May 19, 2021·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Jia-Chen GeDian-Rong Xiu
Aug 18, 2021·Respiratory Medicine Case Reports·Rahul KarnaHammad Arshad

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Methods Mentioned

BETA
surgical resection

Software Mentioned

SPSS
GraphPad Prism
SPSS Statistics
Stat
SEER
RX

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