Surgery for women with endometrioma prior to in vitro fertilisation: proposal for a feasible multicentre randomised clinical trial in the UK

Human Reproduction Open
Abha MaheshwariKatie Gillies

Abstract

Is it feasible to undertake a randomised controlled trial to establish whether surgical removal of endometrioma or not, improves live birth rates from IVF? A randomised controlled trial (RCT) comparing surgery versus no surgery to endometrioma prior to IVF is only feasible in UK if an adaptive rather than traditional study design is used; this would minimise resource wastage and complete the trial in an acceptable time frame. There is wide variation in the management of endometriomas prior to IVF, with decisions about treatment being influenced by personal preferences. This was a mixed-methods study consisting of an online survey of clinicians, a focus group and individual interviews with potential trial participants. Endometriosis and fertility experts across the UK were invited to participate in an online anonymised questionnaire. Potential future trial participants were recruited from a tertiary care fertility centre and invited to participate in either individual interviews or focus groups. Clinicians and potential trial participants confirmed the need for an RCT to inform the management of an endometrioma prior to IVF. There were 126 clinicians who completed the survey, and the majority (70%) were willing to recruit to a t...Continue Reading

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Citations

Jul 10, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Erhan DemirdagMehmet Erdem

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Clinical Trials Mentioned

ISRCTN35880386

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