Surgery in haemophilic patients with inhibitor: 20 years of experience

Haemophilia : the Official Journal of the World Federation of Hemophilia
M Quintana-MolinaF Hernández-Navarro

Abstract

Surgery in haemophilic patients with inhibitor against factor (F)VIII or FIX is high risk. Surgery may be performed with the administration of sufficiently high dose of FVIII in patients with low-response inhibitor or who, despite having a high response, present a low inhibitor titre at the time of surgery. The use of high doses of FX is more complicated in patients with a low-titre FIX inhibitor, as there is a high risk of anaphylactic reactions. In the case of patients with high-titre inhibitors, several treatments have been proposed, such as porcine FVIII, recombinant FVIIa (rFVIIa), and activated prothrombin complex concentrate (APCC). We present our 20 years' experience in the treatment and subsequent management of haemophilic patients with inhibitor in surgery and evaluate the results obtained with the products available for haemostatic control in 64 surgical procedures. The efficacy we obtained with FVIII is good in 100% of the cases described; we had no haemorrhagic complication (HC) in the 18 procedures in which it was used (three major and 15 minor surgery). With APCC we obtained excellent results with only one HC in a synoviorthesis in the form of bleeding and haematomas out of 32 procedures. Good results were obtain...Continue Reading

References

Nov 1, 1991·British Journal of Haematology·R S TedderJ A Garson
Jun 1, 1982·American Journal of Clinical Pathology·N P Ewing, C K Kasper
Nov 1, 1996·World Journal of Surgery·R ScharfT Nowak
Jun 11, 1998·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·J LusherU Hedner
Jan 5, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·C FreiburghausI M Nilsson
Jan 12, 1999·European Journal of Haematology. Supplementum·J Vermylen, K Peerlinck
Sep 1, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·I Scharrer
Oct 26, 1999·Vox Sanguinis·G Mariani, B Kroner
Dec 22, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·C A Leissinger
Sep 30, 2000·Haemophilia : the Official Journal of the World Federation of Hemophilia·V Jiménez-YusteF Hernández-Navarro
Mar 22, 2001·Haemophilia : the Official Journal of the World Federation of Hemophilia·S HayaUNKNOWN Spanish Immune Tolerance Group
Sep 14, 2001·Haemophilia : the Official Journal of the World Federation of Hemophilia·H A CooperU Hedner
Feb 20, 2002·Haemophilia : the Official Journal of the World Federation of Hemophilia·M MoradoF Hernandez-Navarro
Sep 27, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·E C Rodriguez-MerchanH Caviglia
Jan 1, 1996·Haemophilia : the Official Journal of the World Federation of Hemophilia·J Katz

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Citations

Jan 2, 2008·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Anthony ChauRobert Purdy
Mar 30, 2012·Lancet·Erik Berntorp, Amy D Shapiro
Apr 7, 2007·Journal of Pediatric Hematology/oncology·Kimo C StineDavid L Becton
Mar 4, 2006·International Journal of Hematology·Massimo Franchini
May 6, 2015·Expert Review of Hematology·Cindy A LeissingerSandra V Antunes
Jan 26, 2016·Seminars in Hematology·Cindy A Leissinger
Jan 6, 2016·Haemophilia : the Official Journal of the World Federation of Hemophilia·Y DargaudC Négrier
Mar 27, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·L A ValentinoC Negrier
Aug 8, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·P LaurouaV Guérin
Nov 25, 2006·Haemophilia : the Official Journal of the World Federation of Hemophilia·C A Leissinger
Aug 30, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·J M TeitelN Zourikian
Jun 25, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·K FischerV Blanchette
Jan 9, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·C E NeunertG R Buchanan
Dec 18, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·A ObergfellP Mathew
Sep 21, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·E H KrautW-Y Wong
Feb 24, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·H CavigliaR P Bianco
Feb 8, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·L A ValentinoB Goldstein
Nov 20, 2012·British Journal of Haematology·Peter W CollinsUNKNOWN UK Haemophilia Centre Doctors
Mar 7, 2012·British Journal of Haematology·Rolf C R Ljung, Karin Knobe
Aug 29, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·R Kulkarni
Feb 5, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·L A ValentinoK Stine
Aug 23, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·M MakrisR D'Oiron
Jan 4, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·C NégrierT T Yee
Dec 2, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·A BoadasA Ruiz-Sáez
Jun 5, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·A GringeriL G Mantovani
Dec 16, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·A Shapiro, D L Cooper
Sep 20, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·S RangarajanT T Yee
Jun 4, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·C BalkanK Kavakli
Aug 25, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·S ThomasUNKNOWN Brazilian Hemophilia Centers
Jul 17, 2008·Seminars in Hematology·Luciana Scalone
Dec 30, 2015·European Journal of Haematology·María Eva Mingot-CastellanoCarmen Sedano-Balbas
Jul 7, 2017·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Luigi Piero SolimenoStephanie Seremetis
Jan 13, 2017·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Zühre KayaTürkiz Gürsel
Aug 9, 2018·Haemophilia : the Official Journal of the World Federation of Hemophilia·Helena HägglöfSusanna Ranta
Jun 24, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·D BossardG Dirat
Jun 12, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·E C Rodriguez-MerchanA Rodriguez de la Rua
Jul 21, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·S RangarajanJ Wilde
Nov 19, 2019·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Rie ShirayamaAkira Shirahata
Aug 10, 2019·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Daniel P HartMike Makris
Jul 1, 2017·Orthopedics·Christopher R NaccaJohn R Tuttle
Nov 3, 2017·World Journal of Orthopedics·Heidi DanielsonTimo Yrjönen
Jan 4, 2018·Blood Advances·Craig D Seaman, Margaret V Ragni
Dec 7, 2018·Haemophilia : the Official Journal of the World Federation of Hemophilia·Gurhan ErturanNicholas J Goddard

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