Surgery results in significant improvement in growth in children with Crohn's disease refractory to medical therapy

Pediatric Surgery International
Gurpreet Singh RangerDevinder Kumar

Abstract

Inflammatory bowel disease (IBD) in children can cause significant impairment in linear growth, and delay in pubertal onset. The aim of this study was to assess the impact of surgery on linear growth in children with Crohn's disease (CD) who were resistant to medical therapy, and had documented evidence of growth impairment. We performed a retrospective study on eight consecutive patients with refractory disease who had attended the paediatric IBD clinic. All patients underwent surgery as part of their treatment. Height and weight were recorded at least 6 months prior to surgery, at the time of surgery, and 6 months post surgery. Growth velocities and height Z-scores were calculated. All patients had evidence of sustained growth suppression prior to surgery. Three patients had evidence of growth failure. There was a significant increase in height velocity from 0.15 cm/month before surgery to 0.54 cm/month after surgery (P = 0.006). There was also a significant decrease in the modified Harvey-Bradshaw index (HBI) of disease activity from 2.00 before surgery, to 0.84 after surgery (P = 0.003). Improvements in height Z-score and weight velocity after surgery were not significant on statistical analysis. Our study demonstrates that...Continue Reading

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Citations

Dec 3, 2010·Journal of Crohn's & Colitis·Gert Van AsscheUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Jan 29, 2008·Journal of Pediatric Gastroenterology and Nutrition·Folashade A Jose, Melvin B Heyman
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Mar 8, 2017·Journal of Pediatric Gastroenterology and Nutrition·Jorge Amil-DiasUNKNOWN IBD Working Group of ESPGHAN (IBD Porto Group)
Apr 13, 2017·Pediatric Gastroenterology, Hepatology & Nutrition·Seung Kim
Nov 2, 2012·Journal of Pediatric Gastroenterology and Nutrition·Maija PiekkalaKaija-Leena Kolho
Jun 21, 2016·GE Portuguese Journal of Gastroenterology·Rita LourençoAna Isabel Lopes
Jun 3, 2015·World Journal of Gastroenterology : WJG·Colin T Baillie, Jennifer A Smith
Nov 5, 2019·The Surgical Clinics of North America·Nicholas P McKenna, Amy L Lightner
Nov 4, 2020·Biomedicines·Flavia Amaro, Francesco Chiarelli
Jun 30, 2021·Digestive Diseases and Sciences·Rogério Serafim ParraOmar Féres

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