Surgical and catheter delivery of autologous myoblasts in patients with congestive heart failure

Nature Clinical Practice. Cardiovascular Medicine
Shaun R Opie, Nabil Dib

Abstract

Autologous skeletal myoblast (ASM) transplantation is being explored as a possible therapy for patients who have suffered a myocardial infarction. Our initial experience with direct injection during coronary artery bypass grafting demonstrated that this method of delivery was both feasible and safe. In addition, proof of concept of the engraftment and survival of ASMs was shown. However, since many patients who have survived a myocardial infarction are not candidates for surgery, a less invasive delivery method is preferred. We implemented a series of translational research steps to bring catheter-based technology to a clinical application. This included assessing the biocompatibility of the ASM and a novel needle injection catheter using a 3-dimensional endoventricular navigation system, the bioretention and biodistribution of ASMs in a porcine model of myocardial infarction, and the safety and efficacy of ASM transplantation for cardiac function in the porcine model. After catheter functionality had been demonstrated, electromechanical mapping was used to assess the viability in the region of ASM transplantation, and echocardiography, electrocardiogram, and angiography tests were used to assess cardiac function 2 months after...Continue Reading

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Citations

Mar 1, 2009·Journal of Cardiovascular Translational Research·Peter J Psaltis, Stephen G Worthley
Jun 19, 2010·Journal of Cardiovascular Translational Research·Peter J PsaltisStephen G Worthley
Dec 1, 2012·Stem Cells Translational Medicine·Yuji HaraguchiTeruo Okano
Mar 27, 2007·International Journal of Biological Sciences·Joan K Lunney
Nov 17, 2007·Seminars in Cell & Developmental Biology·Robert Zweigerdt
Jan 30, 2007·The Journal of Thoracic and Cardiovascular Surgery·Mauricio A RetuertoTodd K Rosengart
Sep 18, 2007·The Journal of Gene Medicine·Jianping WenGonzalo Hortelano
Feb 28, 2006·Nature Clinical Practice. Cardiovascular Medicine·Warren ShermanTomasz Siminiak
Feb 28, 2006·Nature Clinical Practice. Cardiovascular Medicine·Emerson C Perin, Javier López
Sep 11, 2019·Angiologii︠a︡ i sosudistai︠a︡ khirurgii︠a︡ = Angiology and vascular surgery·Milica MaslovaricEmilija Delević
Apr 21, 2021·Reproductive Sciences·Sivanandane SittadjodyJames J Yoo

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