Surgical closure of PDA in low-weight premature infants

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Rafik MargaryanBruno Murzi

Abstract

Low-weight premature neonates (LWPNs) frequently have haemodynamically significant patent ductus arteriosus (PDA) responsible for serious complications. Cyclooxygenase inhibitors are used for ductal closure. If the medical treatment fails, the PDA can be legated surgically. We present our experience, since 2006, on PDA surgical closure. From 2006 to 2009, of the 518 LWPNs, PDA was present in 109 (21%) infants. The mean gestational age was 29.1 weeks. All patients underwent a medical treatment for PDA closure. Because of the failure of medical treatment, 19 patients (17%) underwent surgical closure. The shift from medical to surgical treatment was related to clinical condition and the echocardiographic appearance of PDA. At operation, the mean age was 17 days (9-42 days). The operation was performed through a left lateral thoracotomy in third intercostal space. PDA was clipped with metallic haemoclipps. No LWPN died as a result of operation (0% early mortality). Post-operative period required inotrophic and diuretic infusion and a more aggressive ventilatory management. In LWPNs, surgical PDA closure is usually given when medical treatment fails. The shift from medical to surgical closure should be based on clinical conditions b...Continue Reading

References

Jun 1, 1977·The Annals of Thoracic Surgery·S C OxnardH D Ruttenberg
Sep 7, 2000·The New England Journal of Medicine·B Van OvermeireJ P Langhendries
Apr 26, 2001·American Journal of Perinatology·E Bancalari
Dec 22, 2005·The Annals of Thoracic Surgery·Sophie JaillardLaurent Storme
Aug 29, 2006·The Journal of Thoracic and Cardiovascular Surgery·Parkash Lal MandhanSpencer Beasley
Jan 9, 2007·Journal of Pediatric Surgery·Mehul V RavalJ Duncan Phillips
Jan 26, 2007·Journal of Perinatology : Official Journal of the California Perinatal Association·M LaughonR Clark
Feb 20, 2007·The Journal of Pediatrics·Nandkishor S KabraUNKNOWN Trial of Indomethacin Prophylaxis in Preterms Investigators
Jan 9, 2008·The Journal of Thoracic and Cardiovascular Surgery·Scott TschuppertAli Dodge-Khatami

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Citations

Apr 14, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Matthew HallidayJames Kiger
Feb 3, 2010·Pharmaceuticals·Karel AllegaertMarc Gewillig
Mar 19, 2014·Pediatrics·Dany E WeiszPrakesh S Shah

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