Surgical debulking of gastrointestinal stromal tumors: is it a reasonable option after second-line treatment with sunitinib?

Journal of Cancer Research and Clinical Oncology
M A PantaleoG Biasco

Abstract

After imatinib treatment, the surgical management of patients affected by gastrointestinal stromal tumor (GIST) has been widely reported and often considered by many oncologists in clinical practice. Surgical results are correlated with disease responsiveness to tyrosine kinase inhibitors and with complete extirpation of all tumor sites. By now, no report specifically addressing surgical management after second-line treatment with sunitinib is still available. Most patients have an unresectable disease and do not have any other therapeutical options except for clinical trials. We report two clinical cases of patients with metastatic GISTs, who underwent surgery after sunitinib, and discuss the surgical management option in this clinical setting. Both our patients had a long, durable stable disease on sunitinib, but one developed a chronic mild bleeding that does not call for emergency surgical interventions and the other one developed chronic heart toxicity. They were proposed to undergo surgery despite the unresectable diseases and received an incomplete resection because of residual metastatic lesions. They restarted sunitinib after surgery. The poor prognosis after sunitinib treatment and the absence of alternative validated...Continue Reading

References

Mar 7, 2000·The American Journal of Pathology·M L LuxJ A Fletcher
Aug 16, 2002·The New England Journal of Medicine·George D DemetriHeikki Joensuu
Dec 4, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael C HeinrichJonathan A Fletcher
Sep 17, 2004·Cancer·Paolo G CasaliSilvana Pilotti
Mar 8, 2005·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Halil OzgüçAbdullah Zorluoglu
Jun 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Cristina R AntonescuRonald P DeMatteo
Jan 13, 2006·The Oncologist·Robert S BenjaminBurton Eisenberg
May 16, 2006·Gastroenterology·Johanna AnderssonBengt Nilsson
May 18, 2006·The British Journal of Surgery·P BümmingB Nilsson
May 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chandrajit P RautMonica M Bertagnolli
Sep 8, 2006·Annals of Surgical Oncology·S BonvalotA Le Cesne
Oct 31, 2006·Annals of Surgical Oncology·Robert H I AndtbackaBarry W Feig

❮ Previous
Next ❯

Citations

Mar 12, 2011·International Journal of Clinical Oncology·Hirotoshi KikuchiHiroyuki Konno
Aug 22, 2009·Wiener medizinische Wochenschrift·Ferdinand PlonerUNKNOWN für das österreichische GIST-Panel
Mar 20, 2013·Wiener medizinische Wochenschrift·Evelyne BareckUNKNOWN Austrian representatives of Medical and Surgical Oncology, Pathology, Radiology, Nuclear Medicine, Gastroenterology, and Lab
Jul 9, 2013·Journal of Medical Genetics·Margherita NanniniMaria A Pantaleo
Nov 14, 2012·Onkologie·Fausto CatenaUNKNOWN GISTologist Study Group
Jan 5, 2010·Wiener klinische Wochenschrift·Ferdinand PlonerThomas Brodowicz
Nov 17, 2009·Cancer Treatment Reviews·Maria Abbondanza PantaleoGuido Biasco
Mar 3, 2009·Hematology/oncology Clinics of North America·Stephane ZalinskiEddie K Abdalla
Oct 24, 2012·International Journal of Surgery Case Reports·Margherita NanniniGuido Biasco
Jul 9, 2014·Frontiers of Medicine·Eric C H LaiWan Yee Lau
Nov 15, 2014·Future Oncology·Maristella SaponaraGuido Biasco
Aug 19, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Avo ArtinyanJoshua D I Ellenhorn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.