Surgical implications of B-RafV600E mutation in fine-needle aspiration of thyroid nodules.

American Journal of Surgery
Michal MekelSareh Parangi

Abstract

Management of patients with thyroid nodules is based on establishing an accurate diagnosis; however, differentiating benign from malignant lesions preoperatively is not always possible using current cytological techniques. Novel molecular testing on cytological material could lead to clearer treatment algorithms. B-Raf(V600E) mutation is the most common genetic alteration in thyroid cancer, specifically found in papillary thyroid cancer (PTC), and usually reported to be associated with aggressive disease. A literature search using PubMed identified all the pertinent literature on the identification and utilization of the B-Raf(V600E) mutation in thyroid cancer. The utility of using B-Raf mutation testing for nodules with indeterminate cytology is limited since many of those nodules (benign and malignant) do not harbor B-Raf mutations. However, when the pathologist sees cytological features suspicious for PTC, B-Raf(V600E) mutation analysis may enhance the assessment of preoperative risks for PTC, directing a more aggressive initial surgical management when appropriate.

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Nov 30, 2011·Current Opinion in Oncology·Constantine TheoharisJulie Ann Sosa
Jan 7, 2014·Annals of Surgical Oncology·Andrea L BaynesJonathan W Serpell
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Aug 12, 2015·Clinical Endocrinology·Alessandro PuzzielloMario Vitale
Sep 9, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lisa M CaroniaManisha H Shah

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