Surgical Management and Adverse Factors for Recurrence and Long-Term Survival in Patients with Hemangiopericytoma

World Neurosurgery
Gui-Jun ZhangJun-Ting Zhang

Abstract

Intracranial hemangiopericytoma is a rare tumor with high recurrence rate. We analyzed adverse factors for recurrence and survival of patients with hemangiopericytoma. We retrospectively reviewed clinical data of 120 patients (mean age, 42 years; 60 male patients) with hemangiopericytoma who were surgically treated in our hospital from December 2008 to January 2016. Gross total resection (GTR) rate was 71.7%. Postoperative adjuvant radiotherapy (PRT) was administered to 63 patients. After median follow-up period of 46.9 months, 35 (29.1%) recurrences and 17 (14.1%) deaths were observed. Progression-free survival (PFS) at 1, 3, and 5 years was 90.8%, 78.5%, and 68.0%, and corresponding overall survival rate was 99.2%, 93.7%, and 82.4%. Higher preoperative Karnofsky performance scale scores (hazard ratio [HR] = 0.896, 95% confidence interval [CI] = 0.845-0.950, P < 0.001), convex surface location (HR = 2.151, 95% CI = 1.042-4.443, P = 0.038), and PRT (HR = 0.339, 95% CI = 0.159-0.724, P = 0.005) were independent favorable factors for PFS. For overall survival, higher preoperative Karnofsky performance scale scores (HR = 0.914, 95% CI = 0.854-0.978, P = 0.009), GTR (HR = 0.291, 95% CI = 0.109-0.777, P = 0.014), and PRT (HR = 0.210...Continue Reading

References

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