Surgical management of bilateral synchronous kidney tumors: functional and oncological outcomes

The Journal of Urology
Matthew N SimmonsInderbir S Gill

Abstract

We evaluated renal functional and oncological outcomes after sequential partial nephrectomy and radical nephrectomy in patients with bilateral synchronous kidney tumors. A total of 220 patients treated from June 1994 to July 2008 were included in the study. Estimated glomerular filtration rate, and overall, cancer specific and recurrence-free survival were assessed. Patients underwent sequential partial nephrectomy (134), partial nephrectomy followed by radical nephrectomy (60) or radical nephrectomy followed by partial nephrectomy (26). Final estimated glomerular filtration rate after bilateral surgery was 59, 36 and 35 ml/minute/1.73 m(2) in these 3 groups, respectively (p <0.001). The order in which partial nephrectomy and radical nephrectomy were conducted did not affect functional outcomes. Overall survival of patients with bilateral cancer was 86% at 5 years and 71% at 10 years, cancer specific survival was 96% at 5 and 10 years, and recurrence-free survival was 73% at 5 years and 44% at 10 years. Overall survival was decreased in patients with tumors larger than 7 cm (p = 0.003). Patients with postoperative stage III or greater chronic kidney disease had decreased overall survival due to noncancer causes (p = 0.007). Pat...Continue Reading

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Citations

Jan 31, 2013·Cardiovascular and Interventional Radiology·Pushpender GuptaRonald J Zagoria
Mar 27, 2013·International Urology and Nephrology·Benjamin WoodsonBenjamin R Lee
Mar 22, 2014·Nitric Oxide : Biology and Chemistry·Oscar McCookUlrich Wachter
Mar 19, 2013·The Journal of Urology·Christina B ChingAmr F Fergany
Oct 23, 2012·The Journal of Urology·Eric A SingerGennady Bratslavsky
Jul 19, 2011·Hematology/oncology Clinics of North America·Yuka YamaguchiSteven C Campbell
Jun 21, 2011·The Journal of Urology·Jane LangeNorman E Breslow
Jul 6, 2016·International Urology and Nephrology·Csaba BercziTibor Flasko
Aug 5, 2011·Current Opinion in Urology

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