Surgical management of carcinoma in situ at ductal resection margins in patients with extrahepatic cholangiocarcinoma

Annals of Gastroenterological Surgery
Toshifumi WakaiTakashi Kobayashi

Abstract

Recent advances in dimensional imaging, surgical technique, and perioperative patient care have resulted in increased rates of complete resection with histopathologically negative margins and improved surgical outcomes in patients with extrahepatic cholangiocarcinoma. However, achieving cancer-free resection margins at ductal stumps in surgery for this disease remains challenging because of longitudinal extension, which is one of the hallmarks of extrahepatic cholangiocarcinoma. When the ductal resection margins are shown to be positive on examination of frozen sections, discrimination between carcinoma in situ and invasive carcinoma is clinically important because residual carcinoma in situ may lead to late local recurrence whereas residual invasive carcinoma is associated with early local recurrence. Residual invasive carcinoma at the ductal margins should be avoided whenever technically feasible. Residual "carcinoma in situ" at the ductal margins appears to be allowed in resection for the advanced disease because it has less effect on survival than other adverse prognostic factors (pN1 and/ or pM1). However, in surgery for early-stage (pTis-2N0M0) extrahepatic cholangiocarcinoma, residual carcinoma in situ at the ductal marg...Continue Reading

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Citations

Jul 25, 2019·The American Journal of Surgical Pathology·Mariko TanakaMasashi Fukayama
Dec 8, 2020·Cancer Reports·Satoshi MatsukumaUNKNOWN Kansai Hepato-Biliary Oncology (KHBO) Group
Feb 10, 2021·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Jun SakataToshifumi Wakai

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