Surgical management of Cushing's disease

Pituitary
Robert F DallapiazzaJohn A Jane

Abstract

Transsphenoidal selective adenomectomy is the first-line treatment for Cushing's disease. At experienced centers, early remission rates after transsphenoidal surgery range from 65 to 98%, however disease relapse frequently occurs with rates ranging from 2 to 35% at long-term follow up. This article discusses recently reported studies on the surgical outcomes from transsphenoidal surgery for Cushing's disease. One of the keys to a successful long-term surgical outcome is meticulous dissection using the adenoma's pseudocapsule as a surgical plane for complete resection. MRI-negative and invasive ACTH-secreting adenomas pose particular challenges for pituitary surgeons.

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Citations

Jan 21, 2016·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Abd Moain Abu Abu DabrhMohammad Hassan Murad
Apr 23, 2016·Journal of Neurosurgery·Russell R LonserEdward H Oldfield
Jan 14, 2018·European Journal of Endocrinology·Natasha IronsidePrashant Chittiboina
Nov 16, 2019·Journal of Clinical Medicine·Hiroshi Nishioka, Shozo Yamada
Sep 16, 2018·Pituitary·Sheri K PalejwalaDaniel F Kelly
Jun 28, 2019·European Endocrinology·Elena V VarlamovMaria Fleseriu
May 16, 2020·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·L I AstafyevaP L Kalinin
Sep 4, 2021·The Journal of Clinical Endocrinology and Metabolism·Regin Jay MallariDaniel F Kelly

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