Surgical management of early-stage hepatocellular carcinoma: resection or transplantation?

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Emily C BellavanceTimothy M Pawlik

Abstract

The surgical management of hepatocellular carcinoma in patients with well-compensated cirrhosis is controversial. The purpose of the current study was to compare the outcome of patients with well-compensated cirrhosis and early stage hepatocellular carcinoma treated with initial hepatic resection versus transplantation. Between 1985 and 2008, 245 patients underwent hepatic resection, and 134 patients underwent liver transplantation for early stage hepatocellular carcinoma. All patients had well-compensated cirrhosis. Prognostic factors were evaluated using univariate and multivariate analyses; survival was calculated using the Kaplan-Meier method. Compared with transplantation, patients undergoing resection had larger tumors and a higher incidence of microscopic vascular invasion. Transplantation was associated with better 5-year disease-free and overall survival compared with resection. Hepatitis status, presence of microscopic vascular invasion, and tumor size were predictors for recurrence, while the presence of microscopic vascular invasion and tumor size conferred an increased risk of death. The disease-free survival advantage with transplantation was more pronounced in hepatitis C patients compared with non-hepatitis and ...Continue Reading

References

Sep 1, 1991·Annals of Surgery·S IwatsukiR Selby
Mar 1, 1991·The British Journal of Surgery·J Belghiti
Mar 1, 1994·Annals of Surgery·D G FarmerR W Busuttil
Jan 1, 1993·Journal of Surgical Oncology. Supplement·G GozzettiA Cavallari
Mar 14, 1996·The New England Journal of Medicine·V MazzaferroL Gennari
Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M LlovetJ Rodés
Jul 31, 1998·Journal of Hepato-biliary-pancreatic Surgery·J DmitrewskiP McMaster
Aug 6, 1998·Gut·S P Pereira, R Williams
Aug 8, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F P SarasinA Hadengue
Mar 17, 1999·Annals of Surgery·S T FanJ Wong
Nov 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M LlovetJ Bruix
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M MalinchocP C ter Borg
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M LlovetG J Gores
Oct 13, 2000·Journal of the American College of Surgeons·K HanazakiJ Amano
Oct 21, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y HoshidaM Omata
May 18, 2001·Archives of Surgery·M M BilimoriaUNKNOWN International Cooperative Study Group on Hepatocellular Carcinoma
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·D M ParkinP Pisani
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi Bruix, Josep M Llovet
Mar 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Nicolas VautheyDavid M Nagorney
May 9, 2003·Surgical Oncology Clinics of North America·Iwao IkaiYoshio Yamaoka
Nov 25, 2003·Annals of Surgery·René AdamHenri Bismuth
Sep 18, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Margarita SalaUNKNOWN Barcelona Clinic Liver Cancer (BCLC) Group
Nov 9, 2004·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Timothy M PawlikJean-Nicolas Vauthey
May 24, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·U ThalheimerA K Burroughs
Jun 24, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Thomas DecaensChristophe Duvoux
Aug 27, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Timothy M PawlikEddie K Abdalla
Sep 27, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Carlos MargaritItxarone Bilbao

❮ Previous
Next ❯

Citations

Apr 1, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Michael A Choti
Apr 27, 2001·Annals of Surgery·A W HemmingR J Howard
Aug 16, 2001·Annals of Surgery·I LevyM Sherman
May 30, 2002·Annals of Surgery·Robert C G MartinDavid P Jaques
May 30, 2002·Annals of Surgery·Alan W HemmingRichard J Howard
Apr 15, 2004·Annals of Surgery·Alan W HemmingRichard J Howard
Jul 30, 2009·Annals of Surgery·Pierre A ClavienMasatoshi Makuuchi
Mar 10, 2009·Annals of Surgical Oncology·Steven C CunninghamTimothy M Pawlik
Jul 7, 2011·Annals of Surgical Oncology·Roberto SantambrogioSavino Bruno
Sep 4, 2012·Annals of Surgical Oncology·Hari NathanTimothy M Pawlik
Sep 6, 2013·Annals of Surgical Oncology·Ioannis HatzarasTimothy M Pawlik
Jul 26, 2013·World Journal of Gastroenterology : WJG·Jian-Yong LeiWen-Tao Wang
Oct 14, 2011·International Journal of Hepatology·Nishant MerchantSteven C Cunningham
Sep 14, 2016·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Nikolaos AndreatosTimothy M Pawlik
Jan 6, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hari NathanTimothy M Pawlik
Jul 27, 2010·Orvosi hetilap·Imre Fehérvári
Aug 15, 2009·Magyar sebészet·Imre Fehérvári
Mar 30, 2010·Pediatric Transplantation·Silja KosolaMikko Pakarinen
Mar 19, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kheng Choon LimPierce K H Chow
Jan 23, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Simone FamularoFabrizio Romano
Dec 15, 2015·Journal of Surgical Oncology·Sanjay MohantyDavid J Bentrem
Jun 21, 2013·Magyar sebészet·Ferenc Jakab
Nov 28, 2014·World Journal of Hepatology·Gonzalo SapisochinRamón Charco
Aug 2, 2016·World Journal of Hepatology·Luis Alberto Batista PeresRaphael Flavio Fachini Cipriani
Nov 23, 2016·World Journal of Hepatology·Linda L WongJun-Fang Ji
Jul 15, 2017·World Journal of Hepatology·Luis Cesar Bredt, Luis Alberto Batista Peres
Mar 16, 2017·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Benjamin MenahemAlexis Laurent
Sep 2, 2019·Surgical Oncology Clinics of North America·Tiffany C LeeShimul A Shah
Sep 23, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Derek ManasRichard A Hubner
Aug 25, 2017·Deutsches Ärzteblatt International·Markus B SchoenbergMarkus Rentsch
Jan 20, 2020·Journal of the American College of Surgeons·Alexander M FagensonKwan N Lau
Oct 6, 2020·Clinics in Liver Disease·Yoshikuni KawaguchiJean-Nicolas Vauthey
Oct 4, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Sepideh GholamiSusanne G Warner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Related Papers

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Jean-Marc BigourdanPhilippe Wolf
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
M Del GaudioAntonio Daniele Pinna
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Alessandro CucchettiAntonio Daniele Pinna
© 2022 Meta ULC. All rights reserved