Surgical management of hepatocellular carcinoma

World Journal of Hepatology
Tony Cy Pang, Vincent Wt Lam

Abstract

Hepatocellular carcinoma (HCC) is the second most common cause of death from cancer worldwide. Standard potentially curative treatments are either resection or transplantation. The aim of this paper is to provide an overview of the surgical management of HCC, as well as highlight current issues in hepatic resection and transplantation. In summary, due to the relationship between HCC and chronic liver disease, the management of HCC depends both on tumour-related and hepatic function-related considerations. As such, HCC is currently managed largely through non-surgical means as the criteria, in relation to the above considerations, for surgical management is still largely restrictive. For early stage tumours, both resection and transplantation offer fairly good survival outcomes (5 years overall survival of around 50%). Selection therefore would depend on the level of hepatic function derangement, organ availability and local expertise. Patients with intermediate stage cancers have limited options, with resection being the only potential for cure. Otherwise, locoregional therapy with transarterial chemoembolization or radiofrequency ablation are viable options. Current issues in resection and transplantation are also briefly disc...Continue Reading

References

Aug 1, 1973·The British Journal of Surgery·R N PughR Williams
Sep 1, 1968·Annals of Surgery·T E StarzlK A Porter
Mar 14, 1996·The New England Journal of Medicine·V MazzaferroL Gennari
Dec 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T de BaereV Bousson
Jul 17, 1998·Transplant International : Official Journal of the European Society for Organ Transplantation·G ColellaD Forti
Mar 17, 1999·Annals of Surgery·S T FanJ Wong
Jun 11, 1999·Annals of Surgery·Y FongL H Blumgart
May 9, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F P SarasinA Hadengue
Jun 8, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F Y YaoJ P Roberts
Jun 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R T PoonJ Wong
Oct 22, 2003·Journal of Hepatology·Filomena ContiYvon Calmus
Dec 12, 2003·Lancet·Josep M LlovetJordi Bruix
Feb 6, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ronnie Tung-Ping Poon, Sheung-Tat Fan
Mar 9, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Yamini K MaddalaGregory Gores
Apr 27, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Francis Y YaoJohn P Roberts
May 26, 2005·Annals of Surgical Oncology·Kelvin K NgUNKNOWN International Cooperative Study Group on Hepatocellular Carcinoma
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN Practice Guidelines Committee, American Association for the Study of Liver Diseases
Dec 8, 2005·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Swee H TehDavid M Nagorney
Apr 7, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Alessandro CucchettiAntonio Daniele Pinna
Sep 12, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Thomas DecaensChristophe Duvoux
Oct 9, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·John F PerrySimone I Strasser
Nov 30, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Takashi ItoShinji Uemoto
Dec 25, 2007·Annals of Surgery·Adel AbulkhirLong R Jiao
Jul 11, 2009·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·John W C ChenSimone I Strasser
Apr 28, 2010·Journal of the American College of Surgeons·Robert C G MartinKelly M McMasters
Jan 25, 2011·Digestive Diseases and Sciences·Yan-Ming ZhouBin Li
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN American Association for the Study of Liver Diseases
Apr 9, 2011·Langenbeck's Archives of Surgery·Yanming ZhouBin Li
Apr 16, 2011·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Reza MirnezamiRobert P Sutcliffe
Jan 17, 2012·American Journal of Surgery·Ahsan RaoIrfan Ahmed
Mar 20, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver, UNKNOWN European Organisation For Research And Treatment Of Cancer
Jun 12, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Wenhua LiangXiaoshun He

❮ Previous
Next ❯

Citations

Jul 22, 2014·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Ser Yee LeeWilliam R Jarnagin
Sep 12, 2015·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Ser Yee LeeMichael I D'Angelica
Jan 6, 2017·Nature Reviews. Gastroenterology & Hepatology·Gonzalo Sapisochin, Jordi Bruix
Mar 2, 2016·World Journal of Experimental Medicine·Roberto MazzantiRenato Tassi
Feb 27, 2016·Current Opinion in Organ Transplantation·Hae Won Lee, Kyung-Suk Suh
Sep 25, 2017·Journal of Clinical and Translational Hepatology·Arno KornbergHelmut Friess
Mar 22, 2019·Digestive Diseases and Sciences·Young-In Yoon, Sung-Gyu Lee
Jul 12, 2018·World Journal of Gastroenterology : WJG·Francesco VasuriDario de Biase
Jun 4, 2020·Annals of Gastroenterological Surgery·Michelle R Ju, Adam C Yopp
Aug 23, 2019·World Journal of Gastrointestinal Oncology·Che-Yu HsuSung-Hsin Kuo
Sep 16, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeffrey S MorrisAhmed Omar Kaseb

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Related Papers

The Medical Clinics of North America
Manuel Mendizabal, K Rajender Reddy
Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology
Ryota Masuzaki, Masao Omata
© 2022 Meta ULC. All rights reserved