Surgical management of insulinoma associated with multiple endocrine neoplasia type I

World Journal of Surgery
D S O'RiordainClive S Grant

Abstract

Insulinoma in patients with multiple endocrine neoplasia (MEN) is a rare condition that because of its usual multicentricity presents difficulties not encountered in sporadic patients. In contrast to gastrinoma, which is the most common pancreatic neoplasm associated with MEN I, malignancy and duodenal tumors are much less common for patients with insulinomas, and excellent palliative medication is not available. Accordingly, there is a much greater reliance on surgical therapy for this group of patients. Between 1970 and 1991 a total of 19 patients had surgical treatment of MEN I-related insulinoma. Each patient had hyperinsulinemic hypoglycemia. One patient, with extensive metastases, had unresectable disease. Of the remaining 18, there were 16 (89%) multiple pancreatic tumors. Tumors were located in the neck, body, or tail in 17 cases, 10 of whom also had tumors in the head. Pancreatic resections performed were 1 total, 12 subtotal (7 also had enucleation of tumors from the pancreatic head), and 5 limited distal resections and/or enucleation (conservative resection). There was no operative mortality. One patient developed pancreatitis, fistula, and diabetes following subtotal resection and enucleation. Postoperative cure was...Continue Reading

References

Mar 15, 1990·The New England Journal of Medicine·M Pipeleers-MarichalP U Heitz
Jul 1, 1988·Archives of Surgery·C S GrantC C Reading
Aug 1, 1984·World Journal of Surgery·N W ThompsonT Mervak

❮ Previous
Next ❯

Citations

Mar 22, 2007·Langenbeck's Archives of Surgery·Daniel CasanovaJulio Freijanes
Aug 2, 2011·Langenbeck's Archives of Surgery·Caroline L LopezDetlef K Bartsch
Aug 28, 2012·Targeted Oncology·Sébastien GaujouxJacques Belghiti
Aug 19, 2005·Current Treatment Options in Oncology·Matthew Kulke
Sep 16, 2003·Cancer Treatment Reviews·Matthew H Kulke
Sep 29, 1999·Endocrinology and Metabolism Clinics of North America·C S Grant
Oct 3, 2002·Surgical Oncology·Matthew J Glascock, Sally E Carty
Aug 30, 2003·Surgical Oncology·Gerard M Doherty
Jan 1, 1997·Surgical Oncology·R D BlissT W Lennard
Dec 6, 2005·Annals of Surgery·Detlef K BartschMatthias Rothmund
Dec 25, 2007·Annals of Surgery·Mehrdad NikfarjamCarlos Fernández-del Castillo
Oct 1, 1995·The Australian and New Zealand Journal of Surgery·B T TehN Hayward
Mar 11, 1998·The Australian and New Zealand Journal of Surgery·C A Proye
Jun 16, 2011·Journal of Hematology & Oncology·Matthew H KulkeJames Yao
Feb 12, 2010·Future Oncology·Joyce J ShinSteven K Libutti
Sep 22, 2010·World Journal of Gastroenterology : WJG·Masayuki Imamura
Dec 24, 2013·World Journal of Gastroenterology : WJG·Francesco TonelliMaria Luisa Brandi
Nov 12, 2013·Current Problems in Surgery·Geoffrey W Krampitz, Jeffrey A Norton
Oct 20, 2009·The Surgical Clinics of North America·Aarti MathurSteven K Libutti
Jan 22, 2008·Best Practice & Research. Clinical Gastroenterology·N Alexakis, J P Neoptolemos
Dec 1, 1996·Baillière's Clinical Gastroenterology·A P GoldstoneJ A Lynn
Oct 29, 2005·Best Practice & Research. Clinical Gastroenterology·Clive S Grant
May 6, 1998·American Journal of Surgery·C Y LoS T Fan
Sep 14, 2015·Surgical Oncology Clinics of North America·Jeffrey A NortonRobert T Jensen
Jul 27, 2001·Best Practice & Research. Clinical Endocrinology & Metabolism·L Fernández-CruzM Sierra
Jul 11, 2006·Clinics in Dermatology·Serge A JabbourRonni Wolf
Sep 19, 2016·Abdominal Radiology·Sampanna Jung RayamajhiPriya Bhosale
Jul 14, 2004·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·N AlexakisJ P Neoptolemos
Oct 29, 2005·Best Practice & Research. Clinical Gastroenterology·Göran AkerströmBritt Skogseid
Oct 20, 2009·The Surgical Clinics of North America·Göran Akerström, Peter Stålberg
Jan 1, 2012·Cancers·Francesco TonelliMaria Luisa Brandi
Feb 25, 1999·The Australian and New Zealand Journal of Surgery·C A Proye, H H Nguyen
Nov 28, 2018·Journal of Surgical Oncology·Mohammad Y ZaidiUNKNOWN and other members of the US Neuroendocrine Tumor Study Group
Feb 12, 2008·World Journal of Surgery·Laureano Fernández-CruzHéctor Rendón
Jun 16, 2009·Internal Medicine·Saori IshigakiKazue Takano
Feb 25, 2006·The British Journal of Surgery·O N TuckerK C Conlon
Jun 1, 2006·Pediatric Surgery International·Shobhana NagrajPaul Johnson
Oct 3, 2009·Endocrine Journal·Francesco TonelliMaria Luisa Brandi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.

Adenoma, Islet Cell

Islet Cell Adenoma arises in the islet cells, which are insulin producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on Islet Cell Adenoma here.