Abstract
The aims of this study were to evaluate the role of surgery in the management of patients with intraabdominal metastases from melanoma and to investigate the neutrophil to lymphocyte ratio (NLR) as prognostic factor in this group of patients. Altogether, 44 patients who underwent surgery for Intraabdominal metastases from melanoma with curative, cytoreductive, or palliative intent were analyzed. There were 77 intraabdominal organ resections performed during the 44 operations. R0 resection was achieved in 19 (43 %) cases. Factors associated with R0 resection were an absence of extra-abdominal metastases, low serum lactate dehydrogenase, involvement of fewer than three sites, and the presence of fewer than three metastatic lesions. The 1-, 3-, and 5-year overall survival rates were, respectively, 79, 66, and 44 % in the curative intent group; 36, 18, and 9 % in the cytoreduction group; and 21, 0 and 0 % in the palliation group (curative intent vs. cytoreduction vs. palliation p < 0.001). By Cox's multivariate analysis, the independent prognostic factors were time from excision of primary melanoma to the diagnosis of intraabdominal metastases, NLR, and residual disease after surgery. Our results confirm the usefulness of major sur...Continue Reading
References
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S SalvadoriK Zier
Aug 17, 2001·British Journal of Cancer·K J O'Byrne, A G Dalgleish
Mar 7, 2002·Current Opinion in Oncology·Peter J Allen, Daniel G Coit
Mar 23, 2004·Annual Review of Immunology·Gavin P DunnRobert D Schreiber
Jul 27, 2004·Annals of Surgery·Daniel DindoPierre-Alain Clavien
Aug 25, 2005·Journal of Surgical Oncology·S R WalshN J Keeling
Mar 15, 2008·World Journal of Surgery·D GomezK R Prasad
Apr 22, 2008·Oncology·Takeharu YamanakaMasanori Fukushima
Jul 2, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A SankiJ F Thompson
Jul 22, 2008·American Journal of Surgery·Charles EvansAngus G Dalgleish
Jul 25, 2008·Nature·Alberto MantovaniFrances Balkwill
Aug 15, 2008·Cytokine·Giovanni GermanoAlberto Mantovani
Jan 9, 2009·Annals of Surgical Oncology·Yoji KishiJean-Nicolas Vauthey
Feb 3, 2009·The Journal of Thoracic and Cardiovascular Surgery·Khaled M SarrafEric Lim
Mar 13, 2009·Nature Reviews. Cancer·Johanna A Joyce, Jeffrey W Pollard
Jun 30, 2009·Annals of Surgery·Karim J HalazunJean C Emond
Oct 23, 2009·Medical Oncology·Mehmet AliustaogluMahmut Gumus
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles M BalchVernon K Sondak
Feb 4, 2010·Journal of Gastrointestinal Cancer·Huanran LiuXiang Hu
Mar 5, 2010·Clinical Pharmacology and Therapeutics·F Balkwill, A Mantovani
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Jan 12, 2011·Annual Review of Immunology·Matthew D VeselyMark J Smyth
Feb 12, 2011·World Journal of Surgery·G GarceaD P Berry
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Mar 8, 2011·Journal of Surgical Oncology·Nabil WasifDonald L Morton
Mar 31, 2011·British Journal of Cancer·W ChuaS J Clarke
Sep 1, 2008·Molecular Medicine Reports·Huanran LiuTakafumi Tabuchi
May 7, 2011·Annals of Surgical Oncology·Reem Z SharaihaJulian A Abrams
Jun 4, 2011·Annals of Surgical Oncology·Basem AzabWarren D Widmann
Aug 23, 2011·Journal of Surgical Oncology·David W OllilaEddy C Hsueh
Jan 13, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jun 16, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelElizabeth Ward
Jan 1, 2011·Oncology Letters·Lianguo KangZhao-Yi Wang
Aug 1, 2012·Oncology Letters·Shouyu WangHuanran Liu
Sep 11, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S MallappaS J D Chadwick
Oct 5, 2012·Journal of Translational Medicine·Jérôme GalonBernard A Fox
Oct 12, 2012·Annals of Surgical Oncology·Daniel R PerezRonald P Dematteo
Dec 12, 2012·Journal of the Korean Surgical Society·Yun Hong Kim, Won Joon Choi
Citations
Sep 8, 2015·The British Journal of Dermatology·J ZaragozaL Machet
Apr 12, 2016·Journal of Surgical Oncology·Ferdinando Carlo Maria CananziVittorio Quagliuolo
Jun 3, 2016·International Journal of Cancer. Journal International Du Cancer·Sara GandiniChiara Martinoli
Aug 22, 2016·Journal of the American Academy of Dermatology·Julia ZaragozaMahtab Samimi
Jul 26, 2018·Medicine·Yingguo DingJianjun Qiao
Aug 2, 2018·Annals of Surgical Oncology·Ryckie G WadeHoward Peach
Sep 10, 2018·Journal of Surgical Oncology·Stefanos KanatsiosDavid E Gyorki
Nov 15, 2018·Journal of Surgical Oncology·Ferdinando Carlo Maria CananziVittorio Lorenzo Quagliuolo
Feb 7, 2020·Nature Reviews. Immunology·Hannah Garner, Karin E de Visser
Apr 6, 2017·Oncotarget·Min DengManni Wang
Feb 13, 2020·The Australasian Journal of Dermatology·Nikolaus B WagnerThomas K Eigentler
Mar 18, 2017·Annals of Surgical Oncology·Jeremy L DavisDaniel G Coit
Jun 6, 2018·Cancer Biomarkers : Section a of Disease Markers·Zhihang TaoXuelei Ma
Nov 14, 2019·Genes·Vratislav HorakHelena Kupcova Skalnikova
Jun 2, 2018·Gastroenterology Research and Practice·Lanyun FengLuming Liu
May 28, 2019·Journal of Surgical Oncology·Joshua T Cohen, Thomas J Miner
Sep 15, 2020·Melanoma Management·Joshua T CohenMichael P Vezeridis
Oct 5, 2019·Cancer·Edmund K BartlettCharlotte E Ariyan
Jul 3, 2021·International Journal of General Medicine·Zhuanbo LuoNing Xu