Surgical Management of Local Retroperitoneal Recurrence of Renal Cell Carcinoma after Radical Nephrectomy

The Journal of Urology
Arun Z ThomasJose A Karam

Abstract

Isolated local retroperitoneal recurrence after radical nephrectomy for renal cell carcinoma poses a therapeutic challenge. We investigated outcomes in patients with localized retroperitoneal recurrence treated with surgical resection. This was a retrospective, single institutional study of 102 patients with retroperitoneal recurrence treated with surgery from 1990 to 2014. Demographics, clinical and pathological features, location of retroperitoneal recurrence and perioperative complications are reported using descriptive statistics. We studied recurrence-free and cancer specific survival using univariate and multivariate analyses. Median age at retroperitoneal recurrence diagnosis was 55 years (IQR 49-64). Cancer was pT3-4 in 62 patients (60.8%) and pN1 in 20 (19.6%). No patients had distant metastatic disease at retroperitoneal recurrence surgery. Median time from nephrectomy to retroperitoneal recurrence diagnosis was 19 months (IQR 5-38.8). The median size of the resected retroperitoneal recurrence was 4.5 cm (IQR 2.7-7). Median followup after recurrence surgery was 32 months (IQR 16-57). Metastatic progression was observed in 60 patients (58.8%) postoperatively. Neoadjuvant and salvage systemic therapy was administered in...Continue Reading

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Citations

Jan 27, 2016·International Journal of Surgery Case Reports·İhsan Yıldızİbrahim Barut
Mar 1, 2016·Surgery Research and Practice·Ömer Acar, Öner Şanlı
Jan 19, 2016·The Journal of Urology·Jennifer M LoboTracey L Krupski
Jan 27, 2018·The Journal of Urology·Paolo CapogrossoUmberto Capitanio
Sep 25, 2017·The Journal of Urology·Erika L WoodJose A Karam
Jun 4, 2019·Open Medicine·Dong WangNianzeng Xing
Jun 5, 2016·Current Opinion in Urology·Marco MoschiniUmberto Capitanio
Jul 30, 2016·Current Opinion in Urology·Saeed DabestaniAxel Bex
Oct 4, 2019·Current Urology·Mark QuinlanNathan Lawrentschuk
Apr 1, 2021·Urologic Oncology·Andrea KokorovicRicardo A Rendon

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