PMID: 9681853Jul 29, 1998Paper

Surgical management of patients with persistent or recurrent medullary thyroid cancer

Journal of Internal Medicine
J F MoleyS A Wells

Abstract

Residual or recurrent medullary thyroid carcinoma (MTC), manifested by elevated calcitonin levels, occurs commonly following primary treatment of MTC. Re-operation in appropriately selected patients is the only treatment modality which consistently and reliably reduces stimulated calcitonin levels, and results in excellent local disease control. We report improved results of surgical management of recurrent MTC in two consecutive series of patients. In our most recent series (1992-96), 38% of patients (17 out of 45) had normal postoperative stimulated calcitonin levels, compared to 28% (nine of 32) in our first series (1990-92). In the most recent series, only 13% (six of 45) of patients had no decrease in calcitonin levels following re-operation, compared to 31% (10 of 32) in our first series (P = 0.07, Fisher's exact test). This improvement has mainly occurred through better preoperative selection of patients, and the institution of routine laparoscopic liver examination preoperatively, which identified metastases in 10 patients, nine of whom had normal CT or MRI imaging.

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Citations

Jun 3, 2008·Surgery Today·Marcos R TavaresAlberto Ferraz
Jun 12, 2002·Current Treatment Options in Oncology·E Kebebew, O H Clark
Jun 22, 2005·Current Treatment Options in Oncology·Frank Jay Quayle, Jeffrey F Moley
Feb 14, 2003·Lancet·Steven I Sherman
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May 28, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association Guidelines Task ForceSamuel A Wells
May 28, 2013·Thyroid : Official Journal of the American Thyroid Association·Frauke BentzienF Michael Yakes
Apr 12, 2007·World Journal of Surgery·Y Nancy You, Samuel A Wells
Feb 27, 2016·Indian Journal of Nuclear Medicine : IJNM : the Official Journal of the Society of Nuclear Medicine, India·Mohana Vamsy ChigurupatiVatturi Venkata Satya Prabhakar Rao
Jun 6, 2007·Hematology/oncology Clinics of North America·Ana O Hoff, Paulo M Hoff
Aug 3, 2006·Surgical Oncology Clinics of North America·Y Nancy YouJeffrey F Moley
May 16, 2009·The Laryngoscope·Shawn M AllenGresham T Richter
Oct 27, 2006·Clinical Journal of Oncology Nursing·Erika L Keatts, Joanne Itano
May 28, 2016·Clinical Endocrinology·Christopher W RoweShaun McGrath
Jun 22, 2007·Anti-cancer Drugs·Sana Intidhar LabidiPatrice Viens
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Jun 22, 2005·Current Treatment Options in Oncology·Amber Traugott, Jeffrey F Moley
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Jan 10, 2001·Current Opinion in Oncology·O Alsanea, O H Clark
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Jun 1, 2000·Cancer Control : Journal of the Moffitt Cancer Center·G W Randolph, D Maniar
Mar 1, 2002·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Arie BittermanOded Cohen
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Jan 31, 2006·Arquivos brasileiros de endocrinologia e metabologia·Ana Luiza MaiaMarcia Khaled Puñales

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