Surgical management of periampullary adenocarcinoma: defining an optimal prognostic lymph node stratification schema

Journal of Cancer
Chaobin HeShengping Li

Abstract

Background: Lymph node (LN) metastasis is a strong predictor of unfavorable prognosis for patients with periampullary adenocarcinoma after surgical resection. We sought to assess the prognostic performance of several LN staging systems, including American Joint Committee on Cancer (AJCC)/ International Union Against Cancer (7th edition) N stage, the total number of LN (TLN), the number of metastatic LN (MLN), the lymph node ratio (LNR) and the log odds of MLNs (LODDS), in patients with periampullary adenocarcinoma after surgical resection and identify the optional LN staging system to accurately stratify patients with different prognoses. Methods: We retrospectively analyzed 205 patients with periampullary adenocarcinoma after surgical resection. The predictive effects of several LN staging systems on overall survival (OS) and progression free survival (PFS) for all included patients and patients with more than 12 TLNs examined were evaluated and compared using the time-dependent receive operating characteristic (ROC) curve and decision curve analysis (DCA), respectively. Results: Eighty-nine patients (43.4%) had LN metastasis and their survival was not significantly decreased compared with patients without LN metastasis. LODDS...Continue Reading

Citations

Mar 5, 2020·International Journal of Cancer. Journal International Du Cancer·Sebastian LundgrenArtur Mezheyeuski
Nov 26, 2020·Annals of Hepato-biliary-pancreatic Surgery·Sundeep Singh SalujaVaibhav Kumar Varshney
Jan 18, 2021·Annals of Surgical Oncology·Marianna V Papageorge, Teviah E Sachs

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Methods Mentioned

BETA
surgical resection
dissection

Software Mentioned

MedCalc
LODDS
SPSS
R

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