PMID: 8466336Apr 1, 1993Paper

Surgical management of pulmonary infections in chronic granulomatous disease of childhood

The Annals of Thoracic Surgery
H W PogrebniakH I Pass

Abstract

Chronic granulomatous disease of childhood is an inheritable disorder of phagocytic cell respiratory burst resulting in recurrent, life-threatening, catalase-positive infections. The lung is the most common site of infection, and pulmonary disease is the primary cause of death in greater than 50% of children with chronic granulomatous disease. Still, the role of surgery in management of this disease remains undefined. Between 1974 and 1990, 19 patients with chronic granulomatous disease required 31 thoracic interventions at our institution. Patients ranged in age from 2.5 to 27 years (mean age, 15 years). Seventeen of 19 patients (89%) had had previous pulmonary infections. Patients presented as toxic (temperature > 38.5 degrees C, chest pain, and cough) in 22 instances before the 31 procedures. Aggressive surgical intervention for diagnosis and extirpation of localized infections was undertaken with lobectomy/pneumonectomy with or without other procedures (5), bisegmentectomy (2), segmentectomy with or without other procedures (5), or wedge with or without other procedures (13). In five instances, an empyema was drained; a chest tube for a sterile collection was placed in one instance. There was one intraoperative death, and 3...Continue Reading

References

Feb 21, 1991·The New England Journal of Medicine·UNKNOWN International Chronic Granulomatous Disease Cooperative Study Group
Mar 16, 1990·JAMA : the Journal of the American Medical Association·J I Gallin, H L Malech
Sep 1, 1990·The Journal of Infectious Diseases·D M MargolisJ I Gallin
Oct 1, 1971·Journal of Pediatric Surgery·S A RobackA S Leonard

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Citations

Aug 1, 1996·Diagnostic Cytopathology·A AbatiD Solomon
Oct 17, 1998·Medicine·B H SegalS M Holland
Apr 16, 1998·The Pediatric Infectious Disease Journal·D Kosmala, D Janner
Oct 15, 2003·Clinical Microbiology Reviews·Timothy Andrews, Kathleen E Sullivan
Sep 15, 2005·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Geetika KhannaYutaka Sato
Oct 23, 2008·AJR. American Journal of Roentgenology·Myrna C B GodoyNestor L Müller
Jul 16, 2013·Allergologia et immunopathologia·S A MahdavianiA A Velayati
Jan 26, 2008·British Journal of Haematology·Reinhard A Seger
Jan 8, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas J WalshUNKNOWN Infectious Diseases Society of America
Jan 11, 2020·Journal of Clinical Immunology·Meera PatrawalaLokesh Guglani
Oct 4, 2012·Expert Review of Anti-infective Therapy·Josef Ben-AriBaruch Wolach
Aug 9, 2016·Journal of Clinical Immunology·Paul L FeingoldRobert T Ripley
Dec 17, 2014·Internal Medicine·Yasutaka KimotoTakahiko Horiuchi

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