Surgical management of stone disease in patients with primary hyperoxaluria

Urology
Alonso CarrascoAmy E Krambeck

Abstract

To present our experience with surgical management of nephrolithiasis in patients with primary hyperoxaluria (PH). A retrospective chart review from 1994 to 2012 was performed to identify patients with diagnosis of PH. A total of 14 patients with PH were identified with a median follow-up of 18.6 years (range, 0.9-51 years). Median ages at initial symptom and subsequent diagnosis were 6.7 years (range, 1.1-35.5 years) and 0.42 years (range, 0-33.25 years), respectively. Patients underwent a total of 54 procedures at our institution, including ureteroscopy (27 [50%]), percutaneous nephrolithotomy (15 [28%]), shock wave lithotripsy (8 [15%]), and combined procedures (4 [7%]). Overall nonintraparenchymal stone-free rate after the first, second, and third procedures were 59%, 76%, and 78%, respectively. On average, 1.6 procedures (range, 1-4) were required to rid patients of symptomatic stones, which subsequently afforded them a mean of 3.62 years (range, 0.25-21.5 years) without the need for additional intervention. There were 6 Clavien grade ≥III complications in 4 patients, including immediate postoperative end-stage renal disease in 3 patients. Despite optimal medical and surgical management, patients experience recurrent acute...Continue Reading

References

Dec 8, 1994·The New England Journal of Medicine·D S MillinerL H Smith
Apr 1, 1993·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·E LeumannT Neuhaus
Aug 30, 2000·Urology·K Kerbl, R V Clayman
Feb 7, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G GambaroA D'Angelo
Jan 25, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Christiaan S van WoerdenFrits A Wijburg
Aug 16, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Bernd Hoppe, Craig B Langman
May 10, 2005·The Journal of Urology·Glenn M PremingerUNKNOWN AUA Nephrolithiasis Guideline Panel)
Jul 1, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Pierre CochatMarie-Odile Rolland
Dec 13, 2007·European Urology·Glenn M PremingerUNKNOWN European Association of Urology
Dec 20, 2008·Advances in Chronic Kidney Disease·Francis X Keeley, Dean G Assimos
Feb 20, 2009·Kidney International·Bernd HoppeDawn S Milliner
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Aug 28, 2010·American Journal of Human Genetics·Ruth BelostotskyYaacov Frishberg
Sep 21, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E J BergstralhUNKNOWN IPHR Investigators
Jul 26, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Andrew D RuleJohn C Lieske
Jan 10, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Jérôme HarambatUNKNOWN European Society for Pediatric Nephrology/European Renal Association-European Dialysis and Transplant Association (ESPN/ERA-
Feb 22, 2012·International Urology and Nephrology·Abdelbasset A BadawyAbdelmoneim M Abuzeid
May 2, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pierre CochatUNKNOWN OxalEurope
Jul 31, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S M van der HoevenJ W Groothoff
Feb 12, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Eslam Al-Abadi, Sally-Anne Hulton
Oct 4, 2013·American Journal of Physiology. Renal Physiology·Elaine M WorcesterDawn Milliner
Nov 29, 2013·The New England Journal of Medicine·Gill Rumsby, Pierre Cochat

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Citations

Dec 12, 2018·Urolithiasis·David J SasDawn S Milliner

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