Surgical margin status and its impact on prostate cancer prognosis after radical prostatectomy: a meta-analysis

World Journal of Urology
Lijin ZhangWei Yang

Abstract

Positive surgical margins (PSMs) correlate with adverse outcomes in numerous solid tumours. However, the prognostic value of PSMs in prostate cancer (PCa) patients who underwent radical prostatectomy remains unclear. Herein, we performed a meta-analysis to evaluate the association between PSMs and the prognostic value for biochemical recurrence-free survival (BRFS), cancer-specific survival (CSS), overall survival (OS), cancer-specific mortality (CSM) and overall mortality (OM) in PCa patients. According to the PRISMA statement, online databases PubMed, EMBASE and Web of Science were searched to identify relevant studies published prior to February 2018. The hazard ratios (HRs) and 95% confidence intervals (95% CIs) were calculated to evaluate the relationship between PSMs and PCa. Ultimately, 32 cohort studies that met the eligibility criteria and involved 141,222 patients (51-65,633 per study) were included in this meta-analysis. The results showed that PSMs were significantly predictive of poorer BRFS (HR = 1.35, 95% CI 1.28-1.48, p < 0.001), CSS (HR = 1.49, 95% CI 1.16-1.90, p = 0.001) and OS (HR = 1.11, 95% CI 1.02-1.20, p = 0.014). In addition, PSMs were significantly associated with higher risk of CSM (HR = 1.23, 95% CI ...Continue Reading

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Citations

Mar 20, 2020·World Journal of Urology·Riccardo Autorino, Francesco Porpiglia
May 16, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·B ZhangR Liu
Aug 21, 2020·Prostate Cancer and Prostatic Diseases·Felix PreisserDerya Tilki
Jul 31, 2020·Aktuelle Urologie·Lothar Weißbach, Christiane Roloff
Apr 17, 2021·Cancer Epidemiology·Win WahArul Earnest
May 5, 2021·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·R Tambwe KayomboS Larré
Aug 27, 2021·Oncology Letters·Wenjing XuQihua Chen

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