Surgical margins and survival after head and neck cancer surgery

BMC Ear, Nose, and Throat Disorders
Reina HaqueDiana B Petitti

Abstract

Mixed results exist as to whether positive surgical margins impact survival. The aim of this study was to determine whether positive surgical margins are indeed associated with decreased survival in patients with primary head and neck cancer. We conducted a retrospective cohort study of 261 cases diagnosed with cancer of the larynx or tongue between 1995 and 1999. Cases were followed through December 31, 2002. Survival curves by margin status were generated by Kaplan-Meier methods. Categorical data were evaluated with odds ratios (OR). All-cause mortality was markedly higher in cases with positive margins as compared with those with negative margins (54% versus 29%, P = 0.005). This pattern also appeared after adjusting for age and sex (OR = 2.97, 95% CI: 1.29-6.84). Our findings suggest that positive surgical margin status is associated with increased mortality. This association also generally persists after adjustment for tumor size, stage, and adjuvant therapy.

References

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Citations

Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Quyen T NguyenRoger Y Tsien
Oct 9, 2007·American Journal of Clinical Oncology·Gary D Becker
Apr 7, 2007·Current Opinion in Otolaryngology & Head and Neck Surgery·Patrick J BradleyC René Leemans
Jun 7, 2011·Journal of Biomedical Optics·Sanjee AbeytungeMilind Rajadhyaksha
Apr 27, 2013·Pharmaceutical Development and Technology·Sarah E LeeRobert M Hoffman
Sep 26, 2013·Advanced Drug Delivery Reviews·Timon Hussain, Quyen T Nguyen
Jan 19, 2012·Head & Neck·Anne Marijn KreeftAlfons J M Balm
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Jan 4, 2017·Annals of Surgery·Kiranya E TipirneniEben Rosenthal
Aug 6, 2014·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Samantha J HauffQuyen T Nguyen
Nov 9, 2017·Antioxidants & Redox Signaling·Xiaofei ChenCristina M Furdui
Jan 10, 2018·Frontiers in Oncology·Tadanobu NagayaHisataka Kobayashi
Oct 23, 2018·JAMA Otolaryngology-- Head & Neck Surgery·Cheryl C NoconMihir K Bhayani
Aug 9, 2013·Nature Reviews. Cancer·Quyen T Nguyen, Roger Y Tsien
Jun 5, 2019·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Liliya BenchetritSaral Mehra
Mar 13, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Nicholas E Wojtynek, Aaron M Mohs
Apr 3, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Romain RivoirardNicolas Magné
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Sep 6, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tiziana MartoneGiorgio Cortesina
Jun 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sean X WangRandal A Otto
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Apr 7, 2007·Current Opinion in Otolaryngology & Head and Neck Surgery

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Methods Mentioned

BETA
surgical resection

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