Surgical options for intrahepatic cholangiocarcinoma

Hepatobiliary Surgery and Nutrition
Kui WangFeng Shen

Abstract

Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer, accounting for 10-15% of primary hepatic malignancy. The incidence and cancer-related mortality of ICC continue to increase worldwide. At present, hepatectomy is still the most effective treatment for ICC patients to achieve long-term survival, although its overall efficacy may not be as good as that for patients with hepatocellular carcinoma (HCC) due to the unique pathogenesis and clinical-pathological profiles of ICC. Viral infection, lithiasis and metabolic factors may all be associated with the pathogenesis of ICC. Poor blood supply, cirrhosis (in rare cases), surrounding organ invasion, and lymph node/distal metastasis have significant impacts on the selection of surgical strategies, surgical resection rate, postoperative complications, recurrence and metastasis. Surgical treatment for ICC includes R0 resection, lymphadenectomy, total gross resection of the involved biliary tracts, blood vessels and surrounding tissues in adjacent organs, and reconstruction. Postoperative adjuvant therapy and local-regional therapy after recurrence may improve survival. Liver transplantation (LT) is reported to have a moderate treatment effect on early I...Continue Reading

Citations

Apr 16, 2018·Journal of Hepato-biliary-pancreatic Sciences·Tomoaki YohShinji Uemoto
Aug 17, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Sung Hyun KimKyung Sik Kim
Jul 13, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiaodong JiaYinying Lu
Nov 10, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Chuan LiLu-Nan Yan
Sep 12, 2020·The Innovation·Mei FengShaokun Shu
Jun 3, 2021·Journal of Clinical Medicine·Guergana PanayotovaKeri E Lunsford

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